The effect of zoledronic acid and denosumab on the mandible and other bones : a ¹⁸F‐NaF‐PET study

Persistent ID (NDL): info:ndljp/pid/12651235

Material type: 博士論文

Author: 伏見, 麻央

Publisher: -

Publication date: 2022-06-15

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Objectives: The primary purpose of this study was to determine whether both zoledronic acid (ZA) and denosumab (Dmab) equally suppress bone remodeling...

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Material Type: 博士論文
Title: The effect of zoledronic acid and denosumab on the mandible and other bones : a ¹⁸F‐NaF‐PET study
Author/Editor: 伏見, 麻央
Author Heading: 伏見, 麻央
Publication Date: 2022-06-15
Publication Date (W3CDTF): 2022-06-15
Alternative Title: ゾレドロン酸とデノスマブが顎骨やその他の正常骨に与える影響〜¹⁸F‐NaF‐PETによる検討〜
Degree grantor/type: 香川大学
Date Granted: 2022-06-15
Date Granted (W3CDTF): 2022-06-15
Dissertation Number: 乙第298号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: Fushimi, Mao
Subject Heading: Osteonecrosis of jaw
Bone metabolism
Bisphosphonate
Denosumab
18F-NaF-PET
Target Audience: 一般
Note (General): Objectives: The primary purpose of this study was to determine whether both zoledronic acid (ZA) and denosumab (Dmab) equally suppress bone remodeling of the normal mandible, and the secondary purpose was to determine the influence of ZA and Dmab on other normal bones.
Methods: 18F-sodium fluoride-positron-emission-tomography (18F-NaF-PET) was used to perform quantitative analysis of the bone metabolism in various parts. The end points of the study were the mean standardized uptake value (SUV) of each member of the ZA group (n = 9), the Dmab group (n = 16), and the Control group (n = 23).
Results: The SUV at the thoracic vertebrae in the ZA group were significantly lower than those of the Dmab and Control group (p < 0.05) In addition, the mean SUVs of the cervical vertebrae in the ZA group were significantly lower than those in the Control group (p < 0.05). There was no significant difference among ZA, Dmab and Control group in the other sites. There was no significant difference between the Dmab and Control groups at all sites.
Conclusions: The remodeling of mandible was not suppressed due to the treatment with anti-resorptive agents. Differences in the mechanisms of action between the BP and Dmab caused the specificity of the effect on the metabolism of normal bone.
Persistent ID (NDL): info:ndljp/pid/12651235
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-03-02T11:18:09+09:00
Format (IMT): application/pdf
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Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/9798
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