Green nut oil or DHA supplementation restored decreased distribution levels of DHA containing phosphatidylcholines in the brain of a mouse model of dementia

• Material Type: 博士論文
• Title: Green nut oil or DHA supplementation restored decreased distribution levels of DHA containing phosphatidylcholines in the brain of a mouse model of dementia
• Author/Editor: Islam, Ariful
• Author Heading: Islam, Ariful
• Publication, Distribution, etc.: MDPI
• Publication Date: 2020-04-16
• Publication Date (W3CDTF): 2020-04-16
• Alternative Title: グリーンナッツオイルまたはDHAの摂取は、認知症モデルマウス脳内のDHA含有ホスファチジルコリン分布レベルの低下を回復させた
• Degree grantor/type: 浜松医科大学
• Date Granted: 2021-09-17
• Date Granted (W3CDTF): 2021-09-17
• Dissertation Number: 甲第887号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: dementia; green nut oil; DHA; SAMP8 mice; DHA-PCs; DESI-MSI
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Dementia is a major public health concern nowadays. Reduced levels of brain docosahexaenoic acid (DHA) and DHA-phosphatidylcholines (DHA-PCs) in dementia patients were reported previously. Recently, we have reported that supplementation of green nut oil (GNO) or DHA improves memory function and distribution levels of brain DHA in senescence accelerated mice P8 (SAMP8). GNO is extracted from Plukenetia volubilis seeds, and SAMP8 is a well-known model mouse of dementia. In this current study, we examined the results of GNO or DHA supplementation in the distribution levels of brain DHA-PCs in same model mouse of dementia using desorption electrospray ionization (DESI) mass spectrometry imaging (MSI).We observed significantly decreased distribution of brain DHA-PCs, PC (16:0_22:6), and PC (18:0_22:6) in SAMP8 mice compared to wild type mice, and GNO or DHA treatment restored the decreased distribution levels of PC (16:0_22:6) and PC (18:0_22:6) in the brain of SAMP8 mice. These results indicate that GNO or DHA supplementation can ameliorate the decreased distribution of brain DHA-PCs in dementia, and could be potentially used for the prevention and treatment of dementia.
• Persistent ID (NDL): info:ndljp/pid/12651254; https://dl.ndl.go.jp/pid/12651254
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-03-02T11:18:09+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00004203; https://hama-med.repo.nii.ac.jp/records/4081
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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