Higher accumulation of docosahexaenoic acid in the vermilion of the human lip than in the skin

• Material Type: 博士論文
• Title: Higher accumulation of docosahexaenoic acid in the vermilion of the human lip than in the skin
• Author/Editor: Mamun, Md. Al
• Author Heading: Mamun, Md. Al
• Publication, Distribution, etc.: MDPI
• Publication Date: 2020-04-17
• Publication Date (W3CDTF): 2020-04-17
• Alternative Title: ドコサヘキサエン酸はヒトの皮膚よりも口唇の赤色部位に多く蓄積する
• Degree grantor/type: 浜松医科大学
• Date Granted: 2021-09-17
• Date Granted (W3CDTF): 2021-09-17
• Dissertation Number: 甲第889号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: DESI-MSI; docosahexaenoic acid; free fatty acids; human lip; skin; vermilion
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; The vermilion of the human lip is a unique facial area because of certain distinguishing features from the adjacent tissues such as the white lip (skin) and oral mucosa. However, the distinction in terms of molecular distribution between the vermilion and skin has remained unexplored. Therefore, we aimed to map the human lip by mass spectrometry imaging to gain understanding of the free fatty acid distribution in the vermilion. The lip specimens trimmed off during cheiloplasty were analyzed using desorption electrospray ionization-mass spectrometry imaging. Distributions of two monounsaturated fatty acids and three polyunsaturated fatty acids were observed in the human lip tissue: palmitoleic acid (POA) and oleic acid (OA) and linoleic acid (LA), arachidonic acid (AA), and docosahexaenoic acid (DHA), respectively. Although POA, OA, LA, and AA were differentially distributed across the vermilion and skin, DHA showed a higher accumulation in the epithelium of the vermilion compared to that in the skin. Our results clearly demonstrated the difference in fatty acid distributions between the vermilion and skin. The highly abundant DHA in the epithelium of the vermilion may have an antioxidant role and may thus protect the lip from aging. Our findings can provide a novel strategy for treating lip disorders.
• Persistent ID (NDL): info:ndljp/pid/12651284; https://dl.ndl.go.jp/pid/12651284
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-03-02T11:18:10+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00004205; https://hama-med.repo.nii.ac.jp/records/4083
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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