Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia

• Material Type: 博士論文
• Title: Desflurane anesthesia shifts the circadian rhythm phase depending on the time of day of anesthesia
• Author/Editor: 今井, 亮
• Author Heading: 今井, 亮
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2020-10-26
• Publication Date (W3CDTF): 2020-10-26
• Alternative Title: デスフルラン麻酔は麻酔時刻に依存して概日リズム位相を変位させる
• Degree grantor/type: 浜松医科大学
• Date Granted: 2022-03-14
• Date Granted (W3CDTF): 2022-03-14
• Dissertation Number: 甲第900号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Desflurane is one of the most frequently used inhalational anesthetics in clinical practice. A circadian rhythm phase-shift after general anesthesia with sevoflurane or isoflurane has been reported in mice, but few studies have reported this effect with desflurane. In the present study, we examined the rest/activity rhythm of mice by counting the number of running wheel rotations, and we found that desflurane anesthesia caused a phase shift in the circadian rhythm that was dependent on the time of day of anesthesia. We also found that desflurane anesthesia altered the relative mRNA expression of four major clock genes (Per2, Bmal, Clock, and Cry1) in the suprachiasmatic nucleus (SCN). These results are important for elucidating the effects of desflurane on the SCN, which is the master clock for the mammalian circadian rhythm. Further studies on the relationship between anesthesia and circadian rhythm may lead to the prevention and treatment of postoperative complications related to circadian rhythms.
• Persistent ID (NDL): info:ndljp/pid/12651522; https://dl.ndl.go.jp/pid/12651522
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-03-02T11:18:10+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00004216; https://hama-med.repo.nii.ac.jp/records/4094
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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