Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer

• Material Type: 博士論文
• Title: Involvement of oral bacteria and oral immunity as risk factors for chemotherapy-induced fever with neutropenia in patients with hematological cancer
• Author/Editor: Sogawa, Yuka; Fukui, Makoto; Nakamura, Shingen; Sogabe, Kimiko; Sumitani, Ryohei; Yoshioka, Masami; Abe, Masahiro; Hinode, Daisuke
• Author Heading: Sogawa, Yuka; Fukui, Makoto; Nakamura, Shingen; Sogabe, Kimiko; Sumitani, Ryohei; Yoshioka, Masami; Abe, Masahiro; Hinode, Daisuke
• Publication, Distribution, etc.: Japanese Society of Hematology|Springer Nature
• Publication Date: 2020-09-03
• Publication Date (W3CDTF): 2020-09-03
• Alternative Title: 血液がん患者の好中球減少に伴う発熱の危険因子としての口腔細菌および口腔免疫との関連; Risk factors for chemotherapy-induced fever with neutropenia
• Degree grantor/type: 徳島大学
• Date Granted: 2021-02-08
• Date Granted (W3CDTF): 2021-02-08
• Dissertation Number: 甲第3472号
• Degree Type: 博士（口腔保健学）
• Text Language Code: eng
• Subject Heading: Fever with neutropenia; Hematological cancer; Risk factor; Secretory immunoglobulin A; Fusobacterium nucleatum
• Target Audience: 一般
• Note (General): The aim of this study is to investigate the association between chemotherapy-induced fever with neutropenia less than 1,500/μL (FwN) and oral bacteria and/or oral immunity in patients with hematological cancer. Thirty-two patients with hematological cancer were enrolled in the study. Secretory immunoglobulin A (sIgA) in saliva and the anaerobic bacteria in tongue coating of each subject was assessed before the first chemotherapy. Eleven subjects had an onset of FwN and 21 subjects did not during the observation periods. It was revealed by the cox-proportional hazard model analysis that the levels of sIgA were low (HR 0.98, p<0.05) and the rate of Fusobacterium nucleatum [F. nucleatum count per total bacterial count (%)] was high (HR 1.65, p<0.05) in patients with FwN onset. Using ROC curve analysis, the optimal cut-off point based on the AUC in the F. nucleatum / sIgA ratio was 0.023, and this model had a 78.4% probability (p<0.01). The risk of FwN onset was also significantly higher among the group of ≥ 0.023 F. nucleatum / sIgA ratio (HR 66.06, p<0.01). These results suggest that the rate of F. nucleatum and the levels of sIgA at baseline might be related to FwN onset as risk factors.
• Persistent ID (NDL): info:ndljp/pid/12651644; https://dl.ndl.go.jp/pid/12651644
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-03-02T11:18:11+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/115932
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp