Brain abnormalities in children with attention-deficit/hyperactivity disorder assessed by multi-delay arterial spin labeling perfusion and voxel-based morphometry

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Brain abnormalities in children with attention-deficit/hyperactivity disorder assessed by multi-delay arterial spin labeling perfusion and voxel-based morphometry

Persistent ID (NDL): info:ndljp/pid/12665059

Material type: 博士論文

Author: Gonchigsuren, Oyundariほか

Publisher: Japan Radiological Society|Springer Nature

Publication date: 2022-01-23

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: Purpose:To obtain an understanding of the correlation between hemodynamic differences and morphological changes as well as potential sex differences i...

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Material Type: 博士論文
Title: Brain abnormalities in children with attention-deficit/hyperactivity disorder assessed by multi-delay arterial spin labeling perfusion and voxel-based morphometry
Author/Editor: Gonchigsuren, Oyundari
Harada, Masafumi
Hisaoka, Sonoka
Higashi, Kohei
Matsumoto, Yuki
Sumida, Nami
Mori, Tatsuo
Ito, Hiromichi
Mori, Kenji
Miyoshi, Mitsuharu
Author Heading: Gonchigsuren, Oyundari
Harada, Masafumi
Hisaoka, Sonoka
Higashi, Kohei
Matsumoto, Yuki
Sumida, Nami
Mori, Tatsuo
Ito, Hiromichi
Mori, Kenji
Miyoshi, Mitsuharu
Publication, Distribution, etc.: Japan Radiological Society|Springer Nature
Publication Date: 2022-01-23
Publication Date (W3CDTF): 2022-01-23
Alternative Title: マルチディレイ動脈スピンラベリング灌流法とボクセルベースの形態計測によって評価された注意欠陥/多動性障害の子供における脳の異常
Degree grantor/type: 徳島大学
Date Granted: 2022-03-23
Date Granted (W3CDTF): 2022-03-23
Dissertation Number: 甲第3595号
Degree Type: 博士（医学）
Text Language Code: eng
Subject Heading: Attention-deficit/hyperactivity disorder
Cerebral blood flow
Magnetic resonance imaging
Pediatrics
Target Audience: 一般
Note (General): Purpose:To obtain an understanding of the correlation between hemodynamic differences and morphological changes as well as potential sex differences in children with ADHD using multi-delay pseudo-continuous arterial spin labeling (pCASL) imaging and voxel-based morphometry (VBM), especially given that previous findings are limited for girls.Materials and methods:We recruited 23 children with ADHD (mean age, 8.3 years; 19 boys; 4 girls) and 24 children without ADHD (mean age, 9.1 years; 13 boys; 11 girls) as controls. All participants underwent 3D multi-delay pCASL and T1-weighted imaging. The voxel-based statistical parameter mapping (SPM) method was used for group-wise comparisons.Results:Compared with controls, children with ADHD exhibited decreased regional cerebral blood flow (rCBF) and gray matter volume (GMV) in the left middle frontal gyrus and left postcentral gyrus. Analysis by sex revealed reduced rCBF and GMV in the left lingual gyrus and left inferior occipital gyrus in boys with ADHD versus controls and increased rCBF and GMV in the left superior frontal gyrus in girls with ADHD.Conclusion:Although our results are preliminary because of small sample sizes, several brain regions exhibit changes in both cerebral perfusion and GMV in the same direction in patients with ADHD, with boys with ADHD showing decreased activity and girls with ADHD displaying increased activity in the fronto-parietal cortices.
Persistent ID (NDL): info:ndljp/pid/12665059
https://dl.ndl.go.jp/pid/12665059
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-03-03T17:22:33+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116981
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