Effect of Lenvatinib treatment on the cell cycle and microRNA profile in hepatocellular carcinoma cells

The cover of this title could differ from library to library.

Available in National Diet Library

国立国会図書館デジタルコレクション

Digital data available

Check on the publisher's website

Effect of Lenvatinib treatment on the cell cycle and microRNA profile in hepatocellular carcinoma cells

Persistent ID (NDL): info:ndljp/pid/12691157

Material type: 博士論文

Author: 中原, 麻衣

Publisher: -

Publication date: 2022-12-27

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 香川大学,博士（医学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Lenvatinib is a tyrosine kinase receptor inhibitor used to treat unresectable hepatocellular carcinoma (HCC). In this study, we investigated the antit...

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Effect of Lenvatinib treatment on the cell cycle and microRNA profile in hepatocellular carcinoma cells
Author/Editor: 中原, 麻衣
Author Heading: 中原, 麻衣
Publication Date: 2022-12-27
Publication Date (W3CDTF): 2022-12-27
Alternative Title: 肝細胞癌の細胞周期とマイクロRNAを介したレンバチニブの治療効果の検討
Degree grantor/type: 香川大学
Date Granted: 2022-12-27
Date Granted (W3CDTF): 2022-12-27
Dissertation Number: 甲第819号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: Nakahara, Mai
Subject Heading: Lenvatinib
cell cycle
cyclin
hepatocellular carcinoma
microRNA
Target Audience: 一般
Note (General): Lenvatinib is a tyrosine kinase receptor inhibitor used to treat unresectable hepatocellular carcinoma (HCC). In this study, we investigated the antitumor effects of Lenvatinib treatment on HCC cell lines. Proliferation was examined in four HCC cell lines (HuH‑7, Hep3B, Li‑7, and PLC/PRF/5) using Cell Counting Kit‑8 assays. Xenograft mouse models were used to assess the effects of Lenvatinib in vivo. Cell cycle, western blotting, and microRNA (miRNA) expression analyses were performed to identify the antitumor inhibitory potential of Lenvatinib on HCC cells. Lenvatinib treatment suppressed proliferation of HuH‑7 and Hep3B, but not Li‑7 and PLC/PRF/5 cells and induced G0/G1 cell cycle arrest and cyclin D1 downregulation in Lenvatinib‑sensitive cells. Lenvatinib treatment also reduced tumor growth in HuH‑7 xenograft mouse models. miRNA microarrays revealed that Lenvatinib treatment altered the expression of miRNAs in HuH7 cells and exosomes. Our results demonstrated the therapeutic potential of Lenvatinib and provide molecular mechanistic insights into its antitumor effects for treating HCC.
Persistent ID (NDL): info:ndljp/pid/12691157
https://dl.ndl.go.jp/pid/12691157
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-03-07T16:07:41+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/11579
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp