ゼブラフィッシュ網膜神経節細胞の生存維持と神経回路形成におけるStrip1の機能解析

• Material Type: 博士論文
• Title: ゼブラフィッシュ網膜神経節細胞の生存維持と神経回路形成におけるStrip1の機能解析
• Author/Editor: Ahmed, Mai
• Author Heading: Ahmed, Mai
• Publication Date: 2022-03-31
• Publication Date (W3CDTF): 2022-03-31
• Alternative Title: Investigating the Function of Strip1 in Ganglion Cell Survival and Neural Circuit Formation of the Developing Zebrafish Retina
• Degree grantor/type: Okinawa Institute of Science and Technology Graduate University
• Date Granted: 2022-03-31
• Date Granted (W3CDTF): 2022-03-31
• Dissertation Number: 甲第93号
• Degree Type: Doctor of Philosophy
• Text Language Code: eng
• Target Audience: 一般
• Note (General): In the vertebrate retina, an interplay between retinal ganglion cells (RGCs), amacrine and bipolar cells establishes a synaptic layer called the inner plexiform layer (IPL). This circuit conveys signals from photoreceptors to visual centers in the brain. However, the molecular mechanisms involved in its development remain poorly understood. Striatin-interacting protein 1 (Strip1) is a core component of the STRIPAK complex, and it has shown emerging roles in embryonic morphogenesis. This study uncovers the importance of Strip1 in inner retina development. Using zebrafish, I show that loss of Strip1 causes defects in IPL formation. In strip1 mutants, RGCs undergo dramatic cell death shortly after birth. Cells in the inner nuclear layer subsequently invade the degenerating RGC layer, leading to a disorganized IPL. Mechanistically, zebrafish Strip1 interacts with its STRIPAK partner, Striatin3, to promote RGC survival by suppressing Jun-mediated apoptosis. In addition to its function in RGC maintenance, Strip1 is required for RGC dendritic patterning, which likely promotes interaction between RGCs and amacrine cells for IPL formation. Taken together, I propose that a series of Strip1- mediated regulatory events coordinates inner retinal circuit formation by maintaining RGCs during development, which ensures proper positioning and neurite patterning of inner retinal neurons.
• DOI: 10.15102/1394.00002364; https://doi.org/10.15102/1394.00002364
• Persistent ID (NDL): info:ndljp/pid/12701608; https://dl.ndl.go.jp/pid/12701608
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-03-09T09:37:53+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15102/1394.00002364; https://oist.repo.nii.ac.jp/records/2625
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-10-11 再収集

2023-10-11 再収集