Altered Microbiota by a High-Fat Diet Accelerates Lethal Myeloid Hematopoiesis Associated with Systemic Socs3 Deficiency

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Altered Microbiota by a High-Fat Diet Accelerates Lethal Myeloid Hematopoiesis Associated with Systemic Socs3 Deficiency

Persistent ID (NDL): info:ndljp/pid/12769012

Material type: 博士論文

Author: Cho, Kaori

Publisher: -

Publication date: 2022-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: The Suppressors of Cytokine Signaling (SOCS) proteins are negative regulators of cytokine signaling required to prevent excessive cellular responses. ...

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Material Type: 博士論文
Title: Altered Microbiota by a High-Fat Diet Accelerates Lethal Myeloid Hematopoiesis Associated with Systemic Socs3 Deficiency
Author/Editor: Cho, Kaori
Author Heading: Cho, Kaori
Publication Date: 2022-03-23
Publication Date (W3CDTF): 2022-03-23
Alternative Title: 高脂肪食による腸内細菌叢の変化は、全身性Socs3 ノックアウトによる致死的な骨髄造血を促進させる
Degree grantor/type: 新潟大学
Date Granted: 2022-03-23
Date Granted (W3CDTF): 2022-03-23
Dissertation Number: 甲第4988号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: 張, かおり
Target Audience: 一般
Note (General): The Suppressors of Cytokine Signaling (SOCS) proteins are negative regulators of cytokine signaling required to prevent excessive cellular responses. In particular, SOCS3 is involved in the regulation of metabolic syndromes, such as obesity and diabetes, by suppressing leptin and insulin signals. SOCS3 also suppresses the inflammatory response associated with metabolic stress, but this specific role remains undefined. Wild-type mice on a high-fat diet (HFD) exhibited only fatty liver, whereas systemic deletion of SOCS3 resulted in excessive myeloid hematopoiesis and hepatic inflammation. In addition, depletion of the gut microbiota resulted in considerable improvement in excess granulopoiesis and splenomegaly, halting the progression of systemic inflammation in SOCS3KO mice on the HFD. This result suggests that intestinal dysbiosis is involved in inflammation associated with SOCS3KO. Although contributing to diet-induced obesity and fatty liver, SOCS3 is nevertheless critical to suppress excess myeloid hematopoiesis and severe systemic inflammation associated with intestinal dysbiosis on HFD.
iScience. 2021, 24(10), 103117.
新大院博(医)第1058号
Persistent ID (NDL): info:ndljp/pid/12769012
https://dl.ndl.go.jp/pid/12769012
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-04-07T23:08:38+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000844
https://niigata-u.repo.nii.ac.jp/records/2000844
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp