Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma

Persistent ID (NDL): info:ndljp/pid/12769027

Material type: 博士論文

Author: Sato, Takeki

Publisher: -

Publication date: 2022-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect ...

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Material Type: 博士論文
Title: Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma
Author/Editor: Sato, Takeki
Author Heading: Sato, Takeki
Publication Date: 2022-03-23
Publication Date (W3CDTF): 2022-03-23
Alternative Title: 肝細胞癌の早期発症に重度の肝脂肪化と軽度大腸炎が重要
Degree grantor/type: 新潟大学
Date Granted: 2022-03-23
Date Granted (W3CDTF): 2022-03-23
Dissertation Number: 甲第4976号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: 佐藤, 毅昂
Subject Heading: Dextran sulfate sodium
Hepatocellular carcinoma
Inflammatory bowel disease
Melanocortin-4 receptor
Non-alcoholic steatohepatitis
Target Audience: 一般
Note (General): The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect of both NASH and IBD on hepatocellular carcinoma (HCC) using a mouse model combining NASH and IBD. The melanocortin 4 receptor-deficient (Mc4r-KO) mice were divided into four groups with or without a high-fat diet (HFD) and with or without dextran sulfate sodium (DSS) to induce colitis, and the differences in liver damage and occurrence of HCC were analyzed. In the HFD+DSS group, the body weight, liver weight/body weight ratio, and serum levels of albumin and alanine aminotransferase were significantly lower than those in the HFD group. We further found that steatosis was significantly lower and lobular inflammation was significantly higher in the HFD+DSS group than those in the HFD group, and that individual steatosis and lobular inflammation state in the HFD+DSS mice varied. We detected HCC only in the HFD+DSS group, and mice with severe steatosis and mild colitis were found to be at high risk of HCC. Presently, the prediction of HCC is very difficult. In some cases, severe colitis reverses the fat accumulation due to appetite loss. Our findings clearly showed that severe steatohepatitis and mild colitis are simultaneously essential for the occurrence of HCC in patients with NASH and IBD.
Biochemical and biophysical research communications. 2021, 566, 36-44.
新大院博(医)第1046号
Persistent ID (NDL): info:ndljp/pid/12769027
https://dl.ndl.go.jp/pid/12769027
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-04-07T23:08:38+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000832
https://niigata-u.repo.nii.ac.jp/records/2000832
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