Loss of Atg2b and Gskip impairs the maintenance of the hematopoietic stem cell pool size

Persistent ID (NDL): info:ndljp/pid/12769053

Material type: 博士論文

Author: Sakai, Shun-suke

Publisher: -

Publication date: 2022-03-23

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 新潟大学,博士（医学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: A germline copy number duplication of chromosome 14q32, which contains ATG2B and GSKIP, was identified in families with myeloproliferative neoplasm (M...

Search by Bookstore

Read this material in an accessible format.

View materials in accessible formats for people with print disabilities (1Type)

Search by Bookstore

Read in Disability Resources

Other Services
- テキストデータ check it on 国立国会図書館デジタルコレクション

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Loss of Atg2b and Gskip impairs the maintenance of the hematopoietic stem cell pool size
Author/Editor: Sakai, Shun-suke
Author Heading: Sakai, Shun-suke
Publication Date: 2022-03-23
Publication Date (W3CDTF): 2022-03-23
Alternative Title: Atg2bとGskip遺伝子欠損は、造血幹細胞のプールサイズの維持を損なう
Role of ATG2B and GSKIP in HSCs
Degree grantor/type: 新潟大学
Date Granted: 2022-03-23
Date Granted (W3CDTF): 2022-03-23
Dissertation Number: 甲第4980号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: 坂井, 俊介
Subject Heading: hematopoietic stem cell
hematopoiesis
ATG2B
GSKIP
autophagy
myeloproliferative neoplasm
Target Audience: 一般
Note (General): A germline copy number duplication of chromosome 14q32, which contains ATG2B and GSKIP, was identified in families with myeloproliferative neoplasm (MPN). Herein, we show that mice lacking both Atg2b and Gskip, but not either alone, exhibited decreased hematopoiesis, resulting in death in utero accompanied by anemia. In marked contrast to MPN patients with duplication of ATG2B and GSKIP, the number of hematopoietic stem cells (HSCs), in particular long-term HSCs, in double knockout fetal livers were significantly decreased due to increased cell death. Although the remaining HSCs still had the ability to differentiate into hematopoietic progenitor cells, the differentiation efficiency was quite low. Remarkably, mice with knockout of Atg2b or Gskip alone did not show any hematopoietic abnormality. Mechanistically, while loss of both genes had no effect on autophagy, it increased the expression of genes encoding enzymes involved in oxidative phosphorylation. Taken together, our results indicate that Atg2b and Gskip play a synergistic effect in maintaining the pool size of HSCs.
Molecular and cellular biology. 2022, 42(1), e0002421.
新大院博(医)第1050号
Persistent ID (NDL): info:ndljp/pid/12769053
https://dl.ndl.go.jp/pid/12769053
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-04-07T23:08:38+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000836
https://niigata-u.repo.nii.ac.jp/records/2000836
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp