Diet-related changes of basal lamina fenestrations in the villous epithelium of the rat small intestine : Statistical analysis on scanning electron microscopy

• Material Type: 博士論文
• Title: Diet-related changes of basal lamina fenestrations in the villous epithelium of the rat small intestine : Statistical analysis on scanning electron microscopy
• Author/Editor: Sato, Masatoshi
• Author Heading: Sato, Masatoshi
• Publication Date: 2022-03-23
• Publication Date (W3CDTF): 2022-03-23
• Alternative Title: ラット小腸絨毛上皮における基底膜の窓の食事による変化 : 走査型電子顕微鏡による統計解析; Intestinal basal lamina change
• Degree grantor/type: 新潟大学
• Date Granted: 2022-03-23
• Date Granted (W3CDTF): 2022-03-23
• Dissertation Number: 甲第4965号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Alias of Author: 佐藤, 公俊
• Target Audience: 一般
• Note (General): The epithelial basal lamina of the small intestine has numerous fenestrations for intraepithelial migration of leukocytes. We reported dynamic changes of fenestrations in dietary conditions. To investigate this phenomenon, we performed statistical analyses using scanning electron microscopy images of the epithelial basal lamina of rat intestinal villi after removal of the villous epithelium by osmium maceration. We examined structural changes in the number and size of fenestrations in the rat jejunum and ileum under fasted and fed states for 24 h. Our findings revealed that, in the jejunum, the number of free cells migrating into the epithelium through fenestrations increased from 2 h after feeding, resulting in an increase in the fenestration size of intestinal villi; the number of free cells then tended to decrease at 6 h after feeding, and the fenestration size also gradually decreased. By contrast, the increase in the fenestration size by feeding was not statistically significant in the ileum. These findings indicate that the number of migrating cells increases in the upper part of the small intestine under dietary conditions, which may influence the absorption efficiency of nutrients including lipids, as well as the induction of nutrient-induced inflammation.; Biomedical research. 2022, 43(1), 11-22.; 新大院博(医)第1035号
• Persistent ID (NDL): info:ndljp/pid/12769062; https://dl.ndl.go.jp/pid/12769062
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• Date Accepted (W3CDTF): 2023-04-07T23:08:38+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://hdl.handle.net/10191/0002000820; https://niigata-u.repo.nii.ac.jp/records/2000820
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp