TRPA1は環境化学物質を検知し、忌避行動を誘発し、睡眠から覚醒させる

• Material Type: 博士論文
• Title: TRPA1は環境化学物質を検知し、忌避行動を誘発し、睡眠から覚醒させる
• Author/Editor: 米満, 亨
• Author Heading: 米満, 亨
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2015-01-28
• Publication Date (W3CDTF): 2015-01-28
• Alternative Title: TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep
• Degree Grantor: 鹿児島大学
• Date Granted: 2015-01-28
• Date Granted (W3CDTF): 2015-01-28
• Dissertation Number: 甲総研第314号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Target Audience: 一般
• Note (General): 出版タイプ： VoR; 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Detecting threats and escaping before serious confrontations are important for animals to avoid danger and death. Transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily, is expressed in a subset of sensory neurons and mediates nociception evoked by pungent chemicals. Using behavioral testing, we found that TRPA1 knockout mice failed to avoid entering a chamber filled with vapor of formalin, allyl isothiocyanate and acrolein. The avoidance behavior was blocked by nasal but not subcutaneous administration of a blocker to TRPA1. We also found that TRPA1 knockout mice did not wake when exposed to formalin during sleep. Additionally, the spinal trigeminal nucleus, the first relay neurons of the trigeminal system, showed massive expression of c-Fos after a brief (3 min) exposure to formalin vapor. TRPA1 seems to be a sentinel for environmental chemicals and induces avoidance behaviors and waking by way of the trigeminal system.Toru Yonemitsu, Chiharu Kuroki, Nobuaki Takahashi, Yasuo Mori, Yuichi Kanmura, Hideki Kashiwadani, Youichirou Ootsuka & Tomoyuki KuwakiTRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleepScientific Reports 3, 3100 (2013)The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: https://doi.org/10.1038/srep03100
• Persistent ID (NDL): info:ndljp/pid/12769214; https://dl.ndl.go.jp/pid/12769214
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/00032145
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-08-05 再収集

2023-08-05 再収集

2024-01-19 再収集

2024-01-19 再収集

2024-01-19 再収集