グルタミントランスポーターSLC1A5の標的化は淡明細胞型腎細胞癌において細胞老化を誘導する

• Material Type: 博士論文
• Title: グルタミントランスポーターSLC1A5の標的化は淡明細胞型腎細胞癌において細胞老化を誘導する
• Author/Editor: 川上, 一誠
• Author Heading: 川上, 一誠
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2023-03-10
• Publication Date (W3CDTF): 2023-03-10
• Alternative Title: Targeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinoma
• Degree grantor/type: 鹿児島大学
• Date Granted: 2023-03-10
• Date Granted (W3CDTF): 2023-03-10
• Dissertation Number: 甲総研第687号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Text Language Code: eng
• Subject Heading: Glutamine transporter; Solute carrier family 1 member 5; V9302; Renal cell carcinoma; Cellular senescence
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; In recent years, cancer metabolism has attracted attention as a therapeutic target, and glutamine metabolism is considered one of the most important metabolic processes in cancer. Solute carrier family 1 member 5 (SLC1A5) is a sodium channel that functions as a glutamine transporter. In various cancer types, SLC1A5 gene expression is enhanced, and cancer cell growth is suppressed by inhibition of SLC1A5. However, the involvement of SLC1A5 in clear cell renal cell carcinoma (ccRCC) is unclear. Therefore, in this study, we evaluated the clinical importance of SLC1A5 in ccRCC using The Cancer Genome Atlas database. Our findings confirmed that SLC1A5 was a prognosis factor for poor survival in ccRCC. Furthermore, loss-of-function assays using small interfering RNAs or an SLC1A5 inhibitor (V9302) in human ccRCC cell lines (A498 and Caki1) showed that inhibition of SLC1A5 significantly suppressed tumor growth, invasion, and migration. Additionally, inhibition of SLC1A5 by V9302 in vivo significantly suppressed tumor growth, and the antitumor effects of SLC1A5 inhibition were related to cellular senescence. Our findings may improve our understanding of ccRCC and the development of new treatment strategies for ccRCC.Issei Kawakami, Hirofumi Yoshino, Wataru Fukumoto, Motoki Tamai, Shunsuke Okamura, Yoichi Osako, Takashi Sakaguchi, Satoru Inoguchi, Ryosuke Matsushita, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa, Hideki EnokidaTargeting of the glutamine transporter SLC1A5 induces cellular senescence in clear cell renal cell carcinomaBiochemical and Biophysical Research Communications 611 (2022) 99-106https://doi.org/10.1016/j.bbrc.2022.04.068
• Persistent ID (NDL): info:ndljp/pid/12769911; https://dl.ndl.go.jp/pid/12769911
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-04-07T23:08:42+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/00032415
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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