Changes in choroidal structure following intravitreal aflibercept therapy for retinal vein occlusion

• Material Type: 博士論文
• Title: Changes in choroidal structure following intravitreal aflibercept therapy for retinal vein occlusion
• Author/Editor: Mitamura, Yoshinori; Enkhmaa, Tserennadmid; Sano, Hiroki; Niki, Masanori; Murao, Fumiko; Egawa, Mariko; Sonoda, Shozo; Sakamoto, Taiji
• Author Heading: Mitamura, Yoshinori; Enkhmaa, Tserennadmid; Sano, Hiroki; Niki, Masanori; Murao, Fumiko; Egawa, Mariko; Sonoda, Shozo; Sakamoto, Taiji
• Publication, Distribution, etc.: BMJ Publishing Group
• Publication Date: 2020-07-03
• Publication Date (W3CDTF): 2020-07-03
• Alternative Title: 網膜静脈閉塞症に対するアフリベルセプト硝子体投与療法後の脈絡膜構造の変化
• Degree grantor/type: 徳島大学
• Date Granted: 2023-01-26
• Date Granted (W3CDTF): 2023-01-26
• Dissertation Number: 甲第3668号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: choroid; imaging; macula; physiology; binarization
• Target Audience: 一般
• Note (General): AimsTo examine the choroidal change accompanying retinal vein occlusion (RVO) in detail, we measured changes in choroidal structure after intravitreal aflibercept (IVA) injections for RVO using binarisation of enhanced depth imaging optical coherence tomographic (EDI-OCT) images and assessed associations with clinical outcome.MethodsRetrospective, observational case series. Forty treatment-naïve patients (10 central, 18 major branch and 12 macular branch RVO) were examined by EDI-OCT before and 1, 3 and 6 months after IVA injections. EDI-OCT images were binarised using ImageJ. Subfoveal cross-sectional areas of the luminal, stromal and total choroid over a 1500 µm span were measured and the stromal area to total choroidal area (S/C) ratio was calculated.ResultsCompared to normal contralateral eyes, afflicted eyes at baseline exhibited significantly greater stromal area (p<0.001), total choroidal area (p=0.001) and S/C ratio (p<0.001), but no difference in luminal area (p=0.083). The stromal area, S/C ratio and total choroidal area were significantly reduced in afflicted eyes at 1, 3 and 6 months after IVA (all p<0.006). Baseline S/C ratio was significantly correlated with baseline visual acuity (VA), baseline central retinal thickness (CRT) and VA and CRT improvement at 1, 3 and 6 months post-treatment even after adjusting for the axial length, age and sex (all p<0.012).ConclusionRVO induces substantial oedema of the choroidal stromal area that is detectable by binarisation of EDI-OCT images. This stromal oedema likely stems from high intraocular vascular endothelial growth factor levels. Changes in choroidal structure may be used to assess severity and prognosis of RVO.
• Persistent ID (NDL): info:ndljp/pid/12863548; https://dl.ndl.go.jp/pid/12863548
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• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-05-05T22:12:33+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/117304
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