Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy

Persistent ID (NDL): info:ndljp/pid/12863801

Material type: 博士論文

Author: Sawaki, Akihiko

Publisher: 三重大学

Publication date: 2020-03-25

Material Format: Digital

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Name of awarding university/degree: 三重大学,博士(医学)

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Note (General)：: application/pdfVincristine (VCR)-induced peripheral neuropathy (VIPN) is a common and life-long toxicity in lymphoma patients receiving current standa...

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Material Type: 博士論文
Title: Genetic polymorphisms and vincristine-induced peripheral neuropathy in patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy
Author/Editor: Sawaki, Akihiko
Author Heading: Sawaki, Akihiko
Publication, Distribution, etc.: 三重大学
Publication Date: 2020-03-25
Publication Date (W3CDTF): 2020-03-25
Degree grantor/type: 三重大学
Date Granted: 2020-03-25
Date Granted (W3CDTF): 2020-03-25
Dissertation Number: 甲医学第2002号
Degree Type: 博士(医学)
Text Language Code: eng
Alias of Author: サワキ, アキヒコ
澤木, 昭彦
Subject Heading: lymphoma
vincristine
neuropathy
CEP72
R-CHOP
Target Audience: 一般
Note (General): application/pdf
Vincristine (VCR)-induced peripheral neuropathy (VIPN) is a common and life-long toxicity in lymphoma patients receiving current standard chemotherapy. The association between VIPN and genetic polymorphisms is largely unknown in adult lymphoma patients. To examine the possible relationship between known genetic polymorphisms in patients with pediatric acute lymphoblastic leukemia and incidence of VIPN in adult patients with B-cell lymphoma, we examined CEP72 rs924607, ETAA1 rs17032980, MTNR1B rs12786200, CYP3A5 rs776746, rs7963521, and rs1045644 genetic polymorphisms in samples from 56 adult patients with B-cell lymphoma who received rituximab, cyclophosphamide, doxorubicin, VCR, and prednisone (R-CHOP) chemotherapy. Mutation analysis was performed by direct sequencing. The median age was 65 years (range, 30–79). The median cumulative dose of VCR was 12 mg (range, 2–16). VIPN was documented in 42 patients (75%), and 9 (16%) had grade 2–4 VIPN. Age, impaired glucose tolerance, number of cycles of R-CHOP, and VCR cumulative dose were not associated with incidence of VIPN. There was no association between the incidence of grade 2–4 or any grade VIPN and these six genetic polymorphisms. These results indicate that CEP72,MTNR1B, ETAA1, CYP3A5, rs7963521, and rs1045644 genetic polymorphisms are not associated with VIPN in patients with B-cell lymphoma who received R-CHOP.
本文/Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan
20p
Persistent ID (NDL): info:ndljp/pid/12863801
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-05-05T22:12:34+09:00
Format (IMT): application/pdf
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Periodical Title (URI): http://hdl.handle.net/10076/00021182
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