Association between acetylcholine receptor characteristics in biceps motor endplates and the epidemiological predictors for conversion from ocular to generalized myasthenia gravis

• Material Type: 博士論文
• Title: Association between acetylcholine receptor characteristics in biceps motor endplates and the epidemiological predictors for conversion from ocular to generalized myasthenia gravis
• Author/Editor: 島, 智秋
• Author Heading: 島, 智秋
• Publication, Distribution, etc.: Nagasaki University School of Medicine
• Publication Date: 2023-03-20
• Publication Date (W3CDTF): 2023-03-20
• Alternative Title: 眼筋型重症筋無力症における、上腕二頭筋運動終板のアセチルコリン受容体量と全身型への疫学的転換予測因子との関連
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2023-03-20
• Date Granted (W3CDTF): 2023-03-20
• Dissertation Number: 甲医歯薬第1520号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: ocular myasthenia gravis; secondary generalized myasthenia gravis; acetylcholine receptor antibody; motor endplate
• Target Audience: 一般
• Note (General): Objective: Epidemiological studies have identified various predictors of conversion from ocular myasthenia gravis (OMG) to secondary generalized myasthenia gravis (SGMG), but none have been confirmed. We investigated the effects of the epidemiological conversion predictors on the destruction of motor endplates in the biceps of patients with OMG and attempted to identify predictors of conversion to SGMG histologically.Methods: Patients with clinically diagnosed OMG who requested immunohistological diagnosis and who underwent muscle biopsy were included in this study. We immunostained the biceps motor endplate and semi-quantitatively measured the density and number of AChRs to determine their association with the epidemiological predictors of conversion from OMG to SGMG.Results: Thirteen patients with OMG were included, of which two patients with positive AChR antibody and concomitant thymoma converted to SGMG. In the classification according to the presence of AChR antibody, the AChR densities tended to be lower in the antibody-positive group than in the negative group (p=0.079), and the AChR numbers were significantly lesser in the AChR antibody-positive group than in the negative group (p=0.019). There were no differences in AChR densities or numbers according to sex, presence of thymic abnormalities, or presence of comorbid autoimmune diseases.Conclusion: In OMG, the AChR numbers in motor endplates of the biceps were significantly lesser in the AChR antibodypositive group than in the negative group. Since the muscle strength tends to decrease as the number of AChRs decreases, AChR antibody positivity may be a predictor of OMG to SGMG conversion, but further studies are needed to confirm.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1520号 学位授与年月日:令和5年3月20日; Author: Tomoaki Shima, Atsushi Nagaoka, Shunsuke Yoshimura, Akira Tsujino; Citation: Acta Medica Nagasakiensia, 66(1), pp.21−27; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2023-03-20); http://hdl.handle.net/10069/00042253
• Persistent ID (NDL): info:ndljp/pid/12864100; https://dl.ndl.go.jp/pid/12864100
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• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-05-05T22:12:35+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://hdl.handle.net/10069/00042354
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