Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method

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Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method

Persistent ID (NDL): info:ndljp/pid/12864341

Material type: 博士論文

Author: Shibata, Osamu

Publisher: -

Publication date: 2022-09-20

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: This research developed an easy-to-use, reproducible pancreatic cancer animal model utilizing pancreas-targeted hydrodynamic gene delivery to deliver ...

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Material Type: 博士論文
Title: Establishment of a pancreatic cancer animal model using the pancreas-targeted hydrodynamic gene delivery method
Author/Editor: Shibata, Osamu
Author Heading: Shibata, Osamu
Publication Date: 2022-09-20
Publication Date (W3CDTF): 2022-09-20
Alternative Title: 膵臓選択的ハイドロダイナミック遺伝子導入法による膵癌モデル動物の確立
Degree grantor/type: 新潟大学
Date Granted: 2022-09-20
Date Granted (W3CDTF): 2022-09-20
Dissertation Number: 甲第5069号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: 柴田, 理
Target Audience: 一般
Note (General): This research developed an easy-to-use, reproducible pancreatic cancer animal model utilizing pancreas-targeted hydrodynamic gene delivery to deliver human pancreatic cancer-related genes to the pancreas of wild-type rats. KRASG12D-induced pancreatic intraepithelial neoplasia lesions showed malignant transformation in the main pancreatic duct at 4 weeks and developed acinar-to-ductal metaplasia, which led to pancreatic ductal adenocarcinoma within 5 weeks, and the gene combination of KRASG12D and YAP enhanced these effects. The repeat hydrodynamic gene delivery of KRASG12D + YAP combination at 4 weeks showed acinar-to-ductal metaplasia in all rats and pancreatic ductal adenocarcinoma in 80% of rats 1 week later. Metastatic tumors in the liver, lymph nodes, and subcutaneous lesions and nervous invasion were confirmed. KRASG12D and YAP combined transfer contributes to the E- to N-cadherin switch in pancreatic ductal adenocarcinoma cells and to tumor metastases. This pancreatic cancer model will speed up pancreatic cancer research for novel treatments and biomarkers for early diagnosis.
Molecular Therapy Nucleic Acids. 2022, 28, 342-352.
新大院博(医)第1082号
Persistent ID (NDL): info:ndljp/pid/12864341
https://dl.ndl.go.jp/pid/12864341
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-05-05T22:12:37+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000961
https://niigata-u.repo.nii.ac.jp/records/2000961
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp