YAP1/TAZ activity maintains vascular integrity and organismal survival

Persistent ID (NDL): info:ndljp/pid/12864351

Material type: 博士論文

Author: Uemura, Shun

Publisher: -

Publication date: 2022-09-20

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: Radiation therapy is one of the major treatment modalities for patients with cancers. However, ionizing radiation (IR) damages not only cancer cells b...

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Material Type: 博士論文
Title: YAP1/TAZ activity maintains vascular integrity and organismal survival
Author/Editor: Uemura, Shun
Author Heading: Uemura, Shun
Publication Date: 2022-09-20
Publication Date (W3CDTF): 2022-09-20
Alternative Title: YAP1/TAZ活性は血管の恒常性と生体の生存に重要である
Degree grantor/type: 新潟大学
Date Granted: 2022-09-20
Date Granted (W3CDTF): 2022-09-20
Dissertation Number: 甲第5078号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: 上村, 駿
Subject Heading: Yes-associated protein 1 (YAP1)
WW domain Containing transcription
regulator 1 (TAZ)
Endothelial cell
Ionizing radiation
Lung
Tight junction
Target Audience: 一般
Note (General): Radiation therapy is one of the major treatment modalities for patients with cancers. However, ionizing radiation (IR) damages not only cancer cells but also the surrounding vascular endothelial cells (ECs). Hippo pathway effector genes Yap1 and Taz are the two transcriptional coactivators that have crucial roles in tissue homeostasis and vascular integrity in various organs. However, their function in adult ECs at the steady state and after IR is poorly understood. Here, we report sex- and context-dependent roles of endothelial YAP1/TAZ in maintaining vascular integrity and organismal survival. EC-specific Yap1/Taz deletion compromised systemic vascular integrity, resulting in lethal circulation failure preferentially in male mice. Furthermore, EC-specific Yap1/Taz deletion induced acute lethality upon sublethal IR that was closely associated with exacerbated systemic vascular dysfunction and circulation failure. Consistent with these findings, RNA-seq analysis revealed downregulation of tight junction genes in Yap1/Taz-deleted ECs. Collectively, our findings highlight the importance of endothelial YAP1/TAZ for maintaining adult vascular function, which may provide clinical implications for preventing organ injury after radiation therapy.
Biochemical and Biophysical Research Communications. 2022, 619, 117-123.
新大院博(医)第1091号
Persistent ID (NDL): info:ndljp/pid/12864351
https://dl.ndl.go.jp/pid/12864351
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-05-05T22:12:37+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000970
https://niigata-u.repo.nii.ac.jp/records/2000970
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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