Daisaikoto improves fatty liver and obesity in melanocortin-4 receptor gene-deficient mice via the activation of brown adipose tissue

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Daisaikoto improves fatty liver and obesity in melanocortin-4 receptor gene-deficient mice via the activation of brown adipose tissue

Persistent ID (NDL): info:ndljp/pid/12864353

Material type: 博士論文

Author: Morita, Shinichi

Publisher: -

Publication date: 2022-09-20

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: Melanocortin 4 receptor gene-knockout (MC4R-KO) mice are known to develop obesity with a high-fat diet. Meanwhile, daisaikoto, one of Kampo medicines,...

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Material Type: 博士論文
Title: Daisaikoto improves fatty liver and obesity in melanocortin-4 receptor gene-deficient mice via the activation of brown adipose tissue
Author/Editor: Morita, Shinichi
Author Heading: Morita, Shinichi
Publication Date: 2022-09-20
Publication Date (W3CDTF): 2022-09-20
Alternative Title: 大柴胡湯は、褐色脂肪組織の活性化を介して、メラノコルチン4受容体遺伝子欠損マウスの脂肪肝と肥満を改善する
Degree grantor/type: 新潟大学
Date Granted: 2022-09-20
Date Granted (W3CDTF): 2022-09-20
Dissertation Number: 甲第5070号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: 森田, 真一
Target Audience: 一般
Note (General): Melanocortin 4 receptor gene-knockout (MC4R-KO) mice are known to develop obesity with a high-fat diet. Meanwhile, daisaikoto, one of Kampo medicines, is a drug that is expected to have therapeutic effects on obesity. Here, we report the efficacy of daisaikoto in MC4R-KO mice. Eight-week-old MC4R-KO male mice (n=12) were divided into three groups as follows: the SD group, which is fed with a standard diet; the HFD group, fed a high-fat diet; and the DSK group, fed with a high-fat diet containing 10% of daisaikoto. After the four-week observation period, mice in each group were sacrificed and samples were collected. The body weights at 12 weeks were significantly higher in the HFD group than in the other groups, indicating that daisaikoto significantly reduced body weight gain and fat deposition of the liver. The metabolome analysis indicated that degradation of triglycerides and fatty acid oxidation in the liver were enhanced by daisaikoto administration. In MC4R-KO mice, the cytoplasm and uncoupling protein 1 expression of brown adipose tissue was decreased; however, it was reversed in the DSK group. In conclusion, daisaikoto has potentially improved fatty liver and obesity, making it a useful therapeutic agent for obesity and fatty liver.
Scientific Reports. 2022, 12, 10105.
新大院博(医)第1083号
Persistent ID (NDL): info:ndljp/pid/12864353
https://dl.ndl.go.jp/pid/12864353
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-05-05T22:12:37+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002000962
https://niigata-u.repo.nii.ac.jp/records/2000962
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp