Effects of EOS789, a novel pan-phosphate transporter inhibitor, on phosphate metabolism : Comparison with a conventional phosphate binder

• Material Type: 博士論文
• Title: Effects of EOS789, a novel pan-phosphate transporter inhibitor, on phosphate metabolism : Comparison with a conventional phosphate binder
• Author/Editor: Tanifuji, Kazuya; Shiozaki, Yuji; Koike, Megumi; Uga, Minori; Komiya, Aoi; Miura, Mizuki; Higashi, Ayami; Shimohata, Takaaki; Takahashi, Akira; Ishizuka, Noriko; Hayashi, Hisayoshi; Ichida, Yasuhiro; Ohtomo, Shuichi; Horiba, Naoshi; Miyamoto, Ken-ichi; Segawa, Hiroko
• Author Heading: Tanifuji, Kazuya; Shiozaki, Yuji; Koike, Megumi; Uga, Minori; Komiya, Aoi; Miura, Mizuki; Higashi, Ayami; Shimohata, Takaaki; Takahashi, Akira; Ishizuka, Noriko; Hayashi, Hisayoshi; Ichida, Yasuhiro; Ohtomo, Shuichi; Horiba, Naoshi; Miyamoto, Ken-ichi; Segawa, Hiroko
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2023-02
• Publication Date (W3CDTF): 2023-02
• Alternative Title: 新規総リン酸トランスポーター阻害剤EOS789のリン代謝に対する効果 : 既存リン吸着剤との比較; The physiological effects of EOS789
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-24
• Date Granted (W3CDTF): 2023-03-24
• Dissertation Number: 甲第3733号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: hyperphosphatemia; CKD; intestine; phosphate transporter
• Target Audience: 一般
• Note (General): Background: Inorganic phosphate (Pi) binders are the only pharmacologic treatment approved for hyperphosphatemia. However, Pi binders induce the expression of intestinal Pi transporters and have limited effects on the inhibition of Pi transport. EOS789, a novel pan-Pi transporter inhibitor, reportedly has potent efficacy in treating hyperphosphatemia. We investigated the properties of EOS789 with comparison to a conventional Pi binder. Methods: Protein and mRNA expression levels of Pi transporters were measured in intestinal and kidney tissues from male Wistar rats fed diets supplemented with EOS789 or lanthanum carbonate (LC). 32Pi permeability was measured in intestinal tissues from normal rats using a chamber. Results: Increased protein levels of NaPi-2b, an intestinal Pi transporter, and luminal Pi removal were observed in rats treated with LC but not in rats treated with EOS789. EOS789 but not LC suppressed intestinal protein levels of the Pi transporter Pit-1 and sodium / hydrogen exchanger isoform 3. 32Pi flux experiments using small intestine tissues from rats demonstrated that EOS789 may affect transcellular Pi transport in addition to paracellular Pi transport. Conclusion: EOS789 has differing regulatory effects on Pi metabolism compared to LC. The properties of EOS789 may compensate for the limitations of LC therapy. The combined or selective use of EOS789 and conventional Pi binders may allow tighter control of hyperphosphatemia.
• Persistent ID (NDL): info:ndljp/pid/12886321; https://dl.ndl.go.jp/pid/12886321
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-06-02T22:06:11+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/118209
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp