Detection of highly abundant small molecules in the stratum corneum of healthy young women using desorption electrospray ionization-mass spectrometry imaging

• Material Type: 博士論文
• Title: Detection of highly abundant small molecules in the stratum corneum of healthy young women using desorption electrospray ionization-mass spectrometry imaging
• Author/Editor: WALIULLAH, A.S.M.
• Author Heading: WALIULLAH, A.S.M.
• Publication Date: 2023-05
• Publication Date (W3CDTF): 2023-05
• Alternative Title: 脱離エレクトロスプレーイオン化質量分析イメージングによる健康な若年女性の皮膚角層に特徴的な低分子の検出
• Degree grantor/type: 浜松医科大学
• Date Granted: 2022-09-16
• Date Granted (W3CDTF): 2022-09-16
• Dissertation Number: 甲第917号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Stratum corneum; DESI-MSI; molecules; skin juvenescence
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Aging reflects skin appearance drastically, which reduces skin juvenescence. However, the small molecules underlying skin juvenescence have not been well studied. We aimed to explore the molecules potentially responsible for young-looking skin. Eleven healthy women aged 24?59 years were recruited and divided into young and middle-aged groups. Multiple layers of the stratum corneum from the cheek area were taken by tape-stripping, followed by desorption electrospray ionization mass spectrometry imaging (DESI-MSI). Overall, five molecules (m/z 284.33, 340.39, 488.39, 628.37, and 863.65) were highly abundant in young subjects. Among them, m/z 284.33 and 340.39 were dominantly detected in each layer of all young subjects. Interestingly, m/z 488.39 and 628.37 were prominent in young subject 4. All of these molecules were gradually decreased in the successive layers of the stratum corneum in subjects 3 and 4 of the young group. These molecules could be endogenous, co-related with youthful skin, or retained from topical cosmetics. Extensive research is indispensable to characterize them and find the relationship between these molecule’s retention capacity in the stratum corneum with different skin parameters. Our findings provide a novel perspective on young skin that could be advantageous in future cosmetic formulations to improve skin juvenescence.
• Persistent ID (NDL): info:ndljp/pid/12887483; https://dl.ndl.go.jp/pid/12887483
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-06-02T22:06:18+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00004270; https://hama-med.repo.nii.ac.jp/records/4148
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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