Social stress alters sleep in FGF21-deficient mice

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Social stress alters sleep in FGF21-deficient mice

Persistent ID (NDL): info:ndljp/pid/12911460

Material type: 博士論文

Author: Hokari, Saoriほか

Publisher: Elsevier

Publication date: 2022-10-13

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: Although several previous studies have suggested a relationship between sleep and the stress response, the mechanism underlying this relationship rema...

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Material Type: 博士論文
Title: Social stress alters sleep in FGF21-deficient mice
Author/Editor: Hokari, Saori
Chikahisa, Sachiko
Shiuchi, Tetsuya
Nakayama, Yoshiaki
Konishi, Morichika
Nishino, Seiji
Itoh, Nobuyuki
Séi, Hiroyoshi
Author Heading: Hokari, Saori
Chikahisa, Sachiko
Shiuchi, Tetsuya
Nakayama, Yoshiaki
Konishi, Morichika
Nishino, Seiji
Itoh, Nobuyuki
Séi, Hiroyoshi
Publication, Distribution, etc.: Elsevier
Publication Date: 2022-10-13
Publication Date (W3CDTF): 2022-10-13
Alternative Title: FGF21欠損マウスにおいて社会的ストレスが睡眠へ及ぼす影響
Degree grantor/type: 徳島大学
Date Granted: 2023-03-23
Date Granted (W3CDTF): 2023-03-23
Dissertation Number: 甲第3693号
Degree Type: 博士（医学）
Text Language Code: eng
Subject Heading: 社会的ストレス
ストレス応答
睡眠
FGF21
ケトン体
Social stress
Stress response
Sleep
Ketone bodies
Target Audience: 一般
Note (General): Although several previous studies have suggested a relationship between sleep and the stress response, the mechanism underlying this relationship remains largely unknown. Here, we show that fibroblast growth factor 21 (FGF21), a lipid metabolism-related hormone, may play a role in this relationship. In this study, we examined differences in the stress response between FGF21 knockout (KO) mice and wild-type (WT) mice after social defeat stress (SDS). When the amount of non-rapid eye movement (NREM) sleep, rapid eye movement (REM) sleep and wakefulness were averaged over the dark period after SDS, only KO mice showed significant differences in NREM sleep and wakefulness. In the social interaction test, KO mice seemed to be more prone to social avoidance. Our real-time (RT) -PCR results revealed that the mRNA expression of the stress- and sleep-related gene gamma-aminobutyric acid A receptor subunit alpha 2 was significantly lower in WT mice than in KO mice. Moreover, KO mice showed lower plasma levels of ketone bodies, which also affect sleep/wake regulation, than WT mice. These results suggested that FGF21 might influence sleep/wake regulation by inducing production of an anti-stress agent and/or ketone bodies, which may result in resilience to social stress.
Persistent ID (NDL): info:ndljp/pid/12911460
https://dl.ndl.go.jp/pid/12911460
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-07-08T03:42:31+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/118282
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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