Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats

Persistent ID (NDL): info:ndljp/pid/12911472

Material type: 博士論文

Author: 蘇, 韶懿

Publisher: Hokkaido University

Publication date: 2023-03-23

Material Format: Digital

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Name of awarding university/degree: 北海道大学,博士(歯学)

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Note (General)：: We investigated the effect of area postrema lesions and selective vagotomy of afferent fibers on emetine-induced nausea in rats. We evaluated the acqu...

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Material Type: 博士論文
Title: Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats
Author/Editor: 蘇, 韶懿
Author Heading: 蘇, 韶懿
Publication, Distribution, etc.: Hokkaido University
Publication Date: 2023-03-23
Publication Date (W3CDTF): 2023-03-23
Alternative Title: ラットにおけるエメチン誘発条件付け味覚忌避に対する最後野破壊および横隔膜下両側迷走神経求心路切除の効果
Degree grantor/type: 北海道大学
Date Granted: 2023-03-23
Date Granted (W3CDTF): 2023-03-23
Dissertation Number: 甲第15483号
Degree Type: 博士(歯学)
Text Language Code: eng
Subject Heading: Emetine
Nausea
Area postrema
Vagal afferent
CTA
NDC: 497
Target Audience: 一般
Note (General): We investigated the effect of area postrema lesions and selective vagotomy of afferent fibers on emetine-induced nausea in rats. We evaluated the acquisition of the conditioned taste avoidance (CTA) to 0.1% saccharin solution after conditioning with emetine dihydrochloride (5.54 mg/kg, i.p., 1% BW). The CTA was measured in three groups of rats: a bilateral subdiaphragmatic afferent vagotomy group, an area postrema lesion group, and a sham lesion group. The bilateral vagotomy and sham groups of rats showed acquisition of CTA within 2 days of the test date. Taste avoidance was never conditioned in the area postrema lesion group. These results indicate that the area postrema plays a crucial role in the induction of emetine-induced nausea.
(主査) 教授舩橋誠, 教授飯村忠浩, 教授⼭本恒之
歯学院（口腔医学専攻）
Su S, Fujita M, Wei Z, Huang H, Yoshizawa T, Inui T, Funahashi M. Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats. Physiol Behav. 2021 Nov 1;241:113565. doi: 10.1016/j.physbeh.2021.113565. Epub 2021 Aug 27.
DOI: 10.14943/doctoral.k15483
https://doi.org/10.14943/doctoral.k15483
Persistent ID (NDL): info:ndljp/pid/12911472
https://dl.ndl.go.jp/pid/12911472
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-07-08T03:42:31+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://dx.doi.org/10.14943/doctoral.k15483
http://hdl.handle.net/2115/89389
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp