The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation

• Material Type: 博士論文
• Title: The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation
• Author/Editor: Yu, Li
• Author Heading: Yu, Li
• Publication, Distribution, etc.: Hokkaido University
• Publication Date: 2023-03-23
• Publication Date (W3CDTF): 2023-03-23
• Alternative Title: 口腔細菌, Streptococcus mutansは、血管炎症を誘発し転移を促進する
• Degree grantor/type: 北海道大学
• Date Granted: 2023-03-23
• Date Granted (W3CDTF): 2023-03-23
• Dissertation Number: 甲第15507号
• Degree Type: 博士(歯学)
• Text Language Code: eng
• Subject Heading: endothelial cells; oral bacteria; oral hygiene; tumor metastasis; vascular inflammation
• NDC: 497
• Target Audience: 一般
• Note (General): Recent studies have demonstrated a relationship between oral bacteria and systemic inflammation. Endothelial cells (ECs), which line blood vessels, control the opening and closing of the vascular barrier and contribute to hematogenous metastasis; however, the role of oral bacteria-induced vascular inflammation in tumor metastasis remains unclear. In this study, we examined the phenotypic changes in vascular ECs following Streptococcus mutans (S. mutans) stimulation in vitro and in vivo. The expression of molecules associated with vascular inflammation and barrier-associated adhesion was analyzed. Tumor metastasis was evaluated after intravenous injection of S. mutans in murine breast cancer hematogenous metastasis model. The results indicated that S. mutans invaded the ECs accompanied by inflammation and NF-κB activation. S. mutans exposure potentially disrupts endothelial integrity by decreasing vascular endothelial (VE)-cadherin expression. The migration and adhesion of tumor cells were enhanced in S. mutans-stimulated ECs. Furthermore, S. mutans-induced lung vascular inflammation promoted breast cancer cell metastasis to the lungs in vivo. The results indicate that oral bacteria promote tumor metastasis through vascular inflammation and the disruption of vascular barrier function. Improving oral hygiene in patients with cancer is of great significance in preventing postoperative pneumonia and tumor metastasis.; (主査) 教授 樋田 京子, 教授 北川 善政, 教授 長谷部 晃; 歯学院（口腔医学専攻）; Yu L, Maishi N, Akahori E, Hasebe A, Takeda R, Matsuda AY, Hida Y, Nam JM, Onodera Y, Kitagawa Y, Hida K. The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation. Cancer Sci. 2022 Nov;113(11):3980-3994.
• DOI: 10.14943/doctoral.k15507; https://doi.org/10.14943/doctoral.k15507
• Persistent ID (NDL): info:ndljp/pid/12912008; https://dl.ndl.go.jp/pid/12912008
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-07-08T03:42:34+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.14943/doctoral.k15507; http://hdl.handle.net/2115/89932
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp