Urinary A- and C-megalin predict progression of diabetic kidney disease : an exploratory retrospective cohort study

Persistent ID (NDL): info:ndljp/pid/12970432

Material type: 博士論文

Author: Iida, Tomomichi

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Publication date: 2023-03-23

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: Aims: Megalin, a proximal tubular endocytosis receptor, is excreted in urine in two forms: ectodomain (A-megalin) and full-length (C-megalin). We expl...

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Material Type: 博士論文
Title: Urinary A- and C-megalin predict progression of diabetic kidney disease : an exploratory retrospective cohort study
Author/Editor: Iida, Tomomichi
Author Heading: Iida, Tomomichi
Publication Date: 2023-03-23
Publication Date (W3CDTF): 2023-03-23
Alternative Title: 尿中A-,C-メガリンの糖尿病性腎臓病患者における腎予後予測性の検討 : 探索的後ろ向きコホート研究
Degree grantor/type: 新潟大学
Date Granted: 2023-03-23
Date Granted (W3CDTF): 2023-03-23
Dissertation Number: 甲第5128号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: 飯田, 倫理
Subject Heading: Diabetic kidney disease
Estimated glomerular filtration rate
Megalin
Target Audience: 一般
Note (General): Aims: Megalin, a proximal tubular endocytosis receptor, is excreted in urine in two forms: ectodomain (A-megalin) and full-length (C-megalin). We explored whether urinary megalin levels can be used as independent prognostic biomarkers in the progression of diabetic kidney disease (DKD). Methods: The associations between baseline urinary A-megalin/creatinine (Cr) and/or C-megalin/Cr levels and the subsequent estimated glomerular filtration rate (eGFR) slope were analyzed using a generalized estimating equation. Patients were categorized into higher or lower groups based on the optimal cutoff values, obtained from a receiver operating characteristic curve, of the two forms of urinary megalin. Results: We retrospectively analyzed 188 patients with type 2 diabetes. The eGFR slopes of the higher A-megalin/Cr and higher C-megalin/Cr groups were - 0.904 and - 0.749 ml/min/1.73 m2/year steeper than those of the lower groups, respectively. Moreover, the eGFR slope was - 1.888 ml/min/1.73 m2/year steeper in the group with both higher A- and higher C-megalin/Cr than in the other group. These results remained significant when adjusted for known urinary biomarkers (albumin, α1-microglobulin, β2-microglobulin, and N-acetyl-β-D-glucosaminidase). Conclusions: Urinary A- and C-megalin/Cr levels are likely to be prognostic biomarkers in the progression of DKD independent of other urinary biomarkers.
Journal of Diabetes and its Complications. 2022, 36(11), 108312.
新大院博(医)第1119号
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-08-04T23:03:36+09:00
Format (IMT): application/pdf
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Periodical Title (URI): http://hdl.handle.net/10191/0002001066
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