Detection and Morphological Analysis of Micro-Ruptured Cortical Arteries in Subdural Hematoma : Three-Dimensional Visualization Using the Tissue-Clearing Clear, Unobstructed, Brain/Body Imaging Cocktails and Computational Analysis Method

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Detection and Morphological Analysis of Micro-Ruptured Cortical Arteries in Subdural Hematoma : Three-Dimensional Visualization Using the Tissue-Clearing Clear, Unobstructed, Brain/Body Imaging Cocktails and Computational Analysis Method

Persistent ID (NDL): info:ndljp/pid/12970438

Material type: 博士論文

Author: Funayama, Kazuhisa

Publisher: -

Publication date: 2023-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: One of the causes of bleeding in subdural hematoma is cortical artery rupture, which is difficult to detect at autopsy. Therefore, reports of autopsy ...

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Material Type: 博士論文
Title: Detection and Morphological Analysis of Micro-Ruptured Cortical Arteries in Subdural Hematoma : Three-Dimensional Visualization Using the Tissue-Clearing Clear, Unobstructed, Brain/Body Imaging Cocktails and Computational Analysis Method
Author/Editor: Funayama, Kazuhisa
Author Heading: Funayama, Kazuhisa
Publication Date: 2023-03-23
Publication Date (W3CDTF): 2023-03-23
Alternative Title: 硬膜下血腫における皮質動脈微小破裂の検出と形態解析 : CUBIC法による組織透明化を用いた3次元画像化
Degree grantor/type: 新潟大学
Date Granted: 2023-03-23
Date Granted (W3CDTF): 2023-03-23
Dissertation Number: 乙第2268号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: 舟山, 一寿
Subject Heading: subdural hematoma
cortical artery
arterial rupture
3D imaging
CUBIC
Target Audience: 一般
Note (General): One of the causes of bleeding in subdural hematoma is cortical artery rupture, which is difficult to detect at autopsy. Therefore, reports of autopsy cases with this condition are limited and hence, the pathogenesis of subdural hematoma remains unclear. Herein, for the detection and morphological analysis of cortical artery ruptures as the bleeding sources of subdural hematoma, we used the tissue-clearing CUBIC (clear, unobstructed, brain/body imaging cocktails and computational analysis) method with light-sheet fluorescence microscopy and reconstructed the two-dimensional and three-dimensional images. Using the CUBIC method, we could clearly visualize and detect cortical artery ruptures that were missed by conventional methods. Indeed, the CUBIC method enables three-dimensional morphological analysis of cortical arteries including the ruptured area, and the creation of cross-sectional two-dimensional images in any direction, which are similar to histopathological images. This highlights the effectiveness of the CUBIC method for subdural hematoma analysis.
Diagnostics. 2022, 12(11), 2875.
新大博(医)第1825号
Persistent ID (NDL): info:ndljp/pid/12970438
https://dl.ndl.go.jp/pid/12970438
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-08-04T23:03:36+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002001083
https://niigata-u.repo.nii.ac.jp/records/2001083
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp