Involvement of DNA Damage Response via the Ccndbp1-Atm-Chk2 Pathway in Mice with Dextran-Sodium-Sulfate-Induced Colitis

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Involvement of DNA Damage Response via the Ccndbp1-Atm-Chk2 Pathway in Mice with Dextran-Sodium-Sulfate-Induced Colitis

Persistent ID (NDL): info:ndljp/pid/12970441

Material type: 博士論文

Author: Horigome, Ryoko

Publisher: -

Publication date: 2023-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士（医学）

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Note (General)：: The dextran sodium sulfate (DSS)-induced colitis mouse model has been widely utilized for human colitis research. While its mechanism involves a respo...

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Material Type: 博士論文
Title: Involvement of DNA Damage Response via the Ccndbp1-Atm-Chk2 Pathway in Mice with Dextran-Sodium-Sulfate-Induced Colitis
Author/Editor: Horigome, Ryoko
Author Heading: Horigome, Ryoko
Publication Date: 2023-03-23
Publication Date (W3CDTF): 2023-03-23
Alternative Title: DSS誘発腸炎モデルマウスの粘膜でのDNA損傷応答にCcndbp1-Atm-Chk2経路が関与する
Degree grantor/type: 新潟大学
Date Granted: 2023-03-23
Date Granted (W3CDTF): 2023-03-23
Dissertation Number: 甲第5109号
Degree Type: 博士（医学）
Text Language Code: eng
Alias of Author: 堀米, 亮子
Subject Heading: DSS
colitis
Ccndbp1
Atm
Chk2
DNA damage
Target Audience: 一般
Note (General): The dextran sodium sulfate (DSS)-induced colitis mouse model has been widely utilized for human colitis research. While its mechanism involves a response to double-strand deoxyribonucleic acid (DNA) damage, ataxia telangiectasia mutated (Atm)-checkpoint kinase 2 (Chk2) pathway activation related to such response remains unreported. Recently, we reported that cyclin D1-binding protein 1 (Ccndbp1) activates the pathway reflecting DNA damage in its knockout mice. Thus, this study aimed to examine the contribution of Ccndbp1 and the Atm-Chk2 pathway in DSS-induced colitis. We assessed the effect of DSS-induced colitis on colon length, disease activity index, and histological score and on the Atm-Chk2 pathway and the subsequent apoptosis in Ccndbp1-knockout mice. DSS-induced colitis showed distal colon-dominant Atm and Chk2 phosphorylation, increase in TdT-mediated dUTP-biotin nick end labeling and cleaved caspase 3-positive cells, and histological score increase, causing disease activity index elevation and colon length shortening. These changes were significantly ameliorated in Ccndbp1-knockout mice. In conclusion, Ccndbp1 contributed to Atm-Chk2 pathway activation in the DSS-induced colitis mouse model, causing inflammation and apoptosis of mucosal cells in the colon.
Journal of Clinical Medicine. 2022, 11(13), 3674.
新大院博(医)第1100号
Persistent ID (NDL): info:ndljp/pid/12970441
https://dl.ndl.go.jp/pid/12970441
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-08-04T23:03:36+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/0002001047
https://niigata-u.repo.nii.ac.jp/records/2001047
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp