小脳発生における顆粒細胞移動とプルキンエ細胞樹状突起選択の計算モデル

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DOI[10.15102/1394.00002565]to the data of the same series

小脳発生における顆粒細胞移動とプルキンエ細胞樹状突起選択の計算モデル

Persistent ID (NDL): info:ndljp/pid/13023743

Material type: 博士論文

Author: Kato, Mizuki

Publisher: -

Publication date: 2022-10-31

Material Format: Digital

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Name of awarding university/degree: Okinawa Institute of Science and Technology Graduate University,Doctor of Philosophy

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Note (General)：: This project aims to investigate the interrelationship between primary dendrite selection of Purkinje cells and migration of their pre-synaptic partne...

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Material Type: 博士論文
Title: 小脳発生における顆粒細胞移動とプルキンエ細胞樹状突起選択の計算モデル
Author/Editor: Kato, Mizuki
Author Heading: Kato, Mizuki
Publication Date: 2022-10-31
Publication Date (W3CDTF): 2022-10-31
Alternative Title: A Computational Model of Granule Cell Migration and Purkinje Cell Primary Dendrite Selection during Cerebellar Development
Degree grantor/type: Okinawa Institute of Science and Technology Graduate University
Date Granted: 2022-10-31
Date Granted (W3CDTF): 2022-10-31
Dissertation Number: 甲第107号
Degree Type: Doctor of Philosophy
Text Language Code: eng
Target Audience: 一般
Note (General): This project aims to investigate the interrelationship between primary dendrite selection of Purkinje cells and migration of their pre-synaptic partner granule cells during cerebellar development. During development of the cerebellar cortex, each Purkinje cell grows more than three dendritic trees, among which a primary tree is selected to develop further, whereas others completely retract. Experimental studies suggested that this selection process is coordinated by physical and synaptic interactions with granule cells. However, technical limitations hinder a continuous observation on multiple populations of the cells. To reveal the mechanism underlying this selection process, we constructed a computational model of dendritic development and granule cell migration, using a new computational framework, NeuroDevSim. Comparisons of the resulting morphologies from the model demonstrated the roles of the selection stage in regulating the growth of the selected primary trees. This thesis presents the first computational model that simultaneously simulates growing Purkinje cells and the dynamics of granule cell migration, revealing the role of physical and synaptic interactions upon dendritic selection. Development of the model is expected to provide new insights in the development of neonatal Purkinje cells and help to track down how cerebellar cortex develops into a normal or abnormal structure.
DOI: 10.15102/1394.00002565
https://doi.org/10.15102/1394.00002565
Persistent ID (NDL): info:ndljp/pid/13023743
https://dl.ndl.go.jp/pid/13023743
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-10-11T15:41:03+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://dx.doi.org/10.15102/1394.00002565
https://oist.repo.nii.ac.jp/records/2835
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp