Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury

Persistent ID (NDL): info:ndljp/pid/13024267

Material type: 博士論文

Author: Tsuboi, Junya

Publisher: 三重大学

Publication date: 2023-03-24

Material Format: Digital

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Name of awarding university/degree: 三重大学,博士(医学)

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Note (General)：: application/pdfFollowing injury, skeletal muscle regenerates but fatty tissue accumulation is seen in aged muscle or muscular dystrophies. Fibro/adipo...

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Material Type: 博士論文
Title: Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury
Author/Editor: Tsuboi, Junya
Author Heading: Tsuboi, Junya
Publication, Distribution, etc.: 三重大学
Publication Date: 2023-03-24
Publication Date (W3CDTF): 2023-03-24
Degree grantor/type: 三重大学
Date Granted: 2023-03-24
Date Granted (W3CDTF): 2023-03-24
Dissertation Number: 乙医学第1084号
Degree Type: 博士(医学)
Text Language Code: eng
Alias of Author: ツボイ, ジュンヤ
坪井, 順哉
Subject Heading: adipogenesis
fibro/adipogenic progenitors
interleukin 13
interleukin 33
lipid raft
aprimary cilia
skeletal muscle regeneration
Target Audience: 一般
Note (General): application/pdf
Following injury, skeletal muscle regenerates but fatty tissue accumulation is seen in aged muscle or muscular dystrophies. Fibro/adipogenic progenitors (FAPs) are key players in these events; however, the effect of primary cilia on FAPs remains unclear. Here, it is reported that genetic ablation of trichoplein (TCHP), a ciliary regulator, induces ciliary elongation on FAPs after injury, which promotes muscle regeneration while inhibiting adipogenesis. The defective adipogenic differentiation of FAPs is attributed to dysfunction of cilia-dependent lipid raft dynamics, which is critical for insulin/Akt signaling. It is also found that interleukin (IL) 13 is substantially produced by intramuscular FAPs, which are upregulated by ciliary elongation and contribute to regeneration. Mechanistically, upon injury, long cilia excessively activate the IL33/ST2/JNK axis to enhance IL13 production, facilitating myoblast proliferation and M2 macrophage polarization. The results indicate that FAPs organize the regenerative responses to skeletal muscle injury via cilia-mediated insulin/Akt and ST2/JNK signaling pathways.
本文/Department of Gastroenterology and Hepatology Mie University Graduate School of Medicine Tsu, Mie 514-8507, Japan
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Persistent ID (NDL): info:ndljp/pid/13024267
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Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-10-11T15:41:06+09:00
Format (IMT): application/pdf
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Periodical Title (URI): http://hdl.handle.net/10076/0002000043
https://mie-u.repo.nii.ac.jp/records/2000043
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