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BackgroundAnaphylaxis following influenza vaccination is a rare but serious problem. The underlying immune responses are not well understood. This study elucidated the IgE and IgG antibody responses in healthy children and adolescents following inactivated influenza vaccines (IIVs).MethodsThe efficacy and safety of quadrivalent IIV (QIV) and trivalent IIV (TIV) were compared in healthy subjects aged 0–18 years. Serum IIV-specific IgE, IgG, and IgG4 levels (sIgE, sIgG, and sIgG4) were measured with ImmunoCAP. Hemagglutination inhibition (HI) assay was performed for each influenza virus subtype. Sera from earlier patients who developed anaphylaxis to different IIVs were similarly tested.ResultsA total of 393 subjects were enrolled: 96 were 6 months−2 years old, 100 were 3–5 years old, 100 were 6–12 years old, and 97 were 13–18 years old. No anaphylaxis was observed. Generally, QIV and TIV induced similar antibody responses. IIV-sIgE levels rose significantly after vaccination in the 6 months–2 years old and 3–5 years old groups, did not change in the 6–12 years old group, and decreased in the 13–18 years old group. In contrast, the IIV-sIgG4/sIgE ratio increased significantly after vaccination in all age groups. Sensitized subjects had significantly higher HI titers and IIV-sIgG levels in the youngest age group and higher IIV-sIgG4 levels in all age groups compared with the non-sensitized. The IIV-sIgG4/sIgE ratio in five patients with anaphylaxis was significantly lower than in age-matched healthy subjects.ConclusionIIVs induce IgE sensitization in healthy children but also robust IgG4 responses that may protect them from anaphylaxis.
本文/Department of Child Health and Development, Mie University Graduate School of Medicine, Tsu, Japan
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Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2023-10-11T15:41:06+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション