Skin stiffness due to decreased blood vessels induces epidermal stem cell senescence
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DOI[10.24659/gsr.9.3_126]to the data of the same series
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- Material Type
- 記事
- Author/Editor
- Ryo Ichijo
- Publication, Distribution, etc.
- Publication Date
- 2022-09-30
- Publication Date (W3CDTF)
- 2022-09-30
- Alternative Title
- 血管が減少することによる皮膚硬化が表皮幹細胞老化を誘導する
- Periodical title
- Glycative stress research
- No. or year of volume/issue
- 9(3)
- Volume
- 9(3)
- ISSN (Periodical Title)
- 2188-3610
- ISSN-L (Periodical Title)
- 2188-3610
- Text Language Code
- engjpn
- DOI
- 10.24659/gsr.9.3_126
- Persistent ID (NDL)
- info:ndljp/pid/13120779
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他
- Acquisition Basis
- オンライン資料収集制度
- Date Accepted (W3CDTF)
- 2023-12-08T11:19:22+09:00
- Date Captured (W3CDTF)
- 2023-05-20
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Periodical Title (Persistent ID (NDL))
- info:ndljp/pid/13120776
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション
- Collection (particular)
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Holding library
- 国立国会図書館
- Call No.
- Z63-D541
- Related Material (URI)
- Related Material (Persistent ID (NDL))
- info:ndljp/pid/13120779
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- Bibliographic ID (NDL)
- 032834802
- Bibliographic Record Category (NDL)
- 632
- Summary, etc.
- Keratinocytes, which make up the majority of the skin epithelium, differentiate from epidermal stem cells and migrate from the basement membrane to the upper layers of the skin, where they are finally shed as grime. Skin stem cells play an important role for skin homeostasis by proliferative capacity and flexibility in response to wound healing and physiological changes. However, factors affecting epidermal stem cell proliferation remain unresolved. In this study, we focused on Piezo1, a mechano-ion channel that recognizes "stiffness" and becomes activated, and clarified the mechanism by which the mechanical environment induces epidermal stem cell senescence. A new mechanism of skin aging has been identified in which Ptx3 expression from dermal fibroblasts increases with aging, which induces vascular atrophy and dermal stiffening, and induces age-related alterations in epidermal stem cells due to long-term calcium influx via Piezo1. This finding may be useful for the development of new functional ingredients with a novel mechanism "Ptx3 regulation."
- DOI
- 10.24659/gsr.9.3_126
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- Keratinocytes, which make up the majority of the skin epithelium, differentiate from epidermal stem cells and migrate from the basement membrane to the upper layers of the skin, where they are finally shed as grime. Skin stem cells play an important role for skin homeostasis by proliferative capacity and flexibility in response to wound healing and physiological changes. However, factors affecting epidermal stem cell proliferation remain unresolved. In this study, we focused on Piezo1, a mechano-ion channel that recognizes "stiffness" and becomes activated, and clarified the mechanism by which the mechanical environment induces epidermal stem cell senescence. A new mechanism of skin aging has been identified in which Ptx3 expression from dermal fibroblasts increases with aging, which induces vascular atrophy and dermal stiffening, and induces age-related alterations in epidermal stem cells due to long-term calcium influx via Piezo1. This finding may be useful for the development of new functional ingredients with a novel mechanism "Ptx3 regulation."
- DOI
- 10.24659/gsr.9.3_126
- Related Material (URI)
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベース雑誌記事索引データベース
- Bibliographic ID (NDL)
- 03283480213120779