Generation of short chain aldehydes and glyceraldehyde 3-phosphate dehydrogenase (GAPDH)
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DOI[10.24659/gsr.9.3_129]to the data of the same series
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- Material Type
- 記事
- Author/Editor
- Kenji SatoYifeng ZhengAgustin Martin-Morales
- Publication, Distribution, etc.
- Publication Date
- 2022-09-30
- Publication Date (W3CDTF)
- 2022-09-30
- Alternative Title
- 生体内での短鎖アルデヒドの生成とglyceraldehyde 3-phosphate dehydrogenase(GAPDH)
- Periodical title
- Glycative stress research
- No. or year of volume/issue
- 9(3)
- Volume
- 9(3)
- ISSN (Periodical Title)
- 2188-3610
- ISSN-L (Periodical Title)
- 2188-3610
- Text Language Code
- engjpn
- DOI
- 10.24659/gsr.9.3_129
- Persistent ID (NDL)
- info:ndljp/pid/13120780
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他
- Acquisition Basis
- オンライン資料収集制度
- Date Accepted (W3CDTF)
- 2023-12-08T11:19:22+09:00
- Date Captured (W3CDTF)
- 2023-05-20
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Periodical Title (Persistent ID (NDL))
- info:ndljp/pid/13120776
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション
- Collection (particular)
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Holding library
- 国立国会図書館
- Call No.
- Z63-D541
- Related Material (URI)
- Related Material (Persistent ID (NDL))
- info:ndljp/pid/13120780
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- Bibliographic ID (NDL)
- 032834803
- Bibliographic Record Category (NDL)
- 632
- Summary, etc.
- Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an enzyme involved in the glycolytic pathway. From the substrates of GAPDH, toxic aldehydes, such as glyceraldehyde and methylglyoxal, can be generated. Inhibition of GAPDH in HCT116 cells by koningin acid increased glyceraldehyde. Animal experiments demonstrated that high fat diet-feeding significantly decreased mice liver GAPDH in protein level with increase of lipid peroxidation, liver damage, and shortage of liver cysteine. On the other hand, some food compounds, a water extract of chlorella and its constituent (phenethylamine), ameliorated high fat diet-induced decrease of GAPDH and following pathological events. Treatment with these compounds significantly decreased liver methylglyoxal. Cysteine can react with short chain glyceraldehydes including methylglyoxal and convert them to nontoxic metabolites. These facts indicate that decrease of GAPDH can increase toxic aldehydes in liver and induce liver damage and some food compounds can ameliorate liver damage via recovering GAPDH.
- DOI
- 10.24659/gsr.9.3_129
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an enzyme involved in the glycolytic pathway. From the substrates of GAPDH, toxic aldehydes, such as glyceraldehyde and methylglyoxal, can be generated. Inhibition of GAPDH in HCT116 cells by koningin acid increased glyceraldehyde. Animal experiments demonstrated that high fat diet-feeding significantly decreased mice liver GAPDH in protein level with increase of lipid peroxidation, liver damage, and shortage of liver cysteine. On the other hand, some food compounds, a water extract of chlorella and its constituent (phenethylamine), ameliorated high fat diet-induced decrease of GAPDH and following pathological events. Treatment with these compounds significantly decreased liver methylglyoxal. Cysteine can react with short chain glyceraldehydes including methylglyoxal and convert them to nontoxic metabolites. These facts indicate that decrease of GAPDH can increase toxic aldehydes in liver and induce liver damage and some food compounds can ameliorate liver damage via recovering GAPDH.
- DOI
- 10.24659/gsr.9.3_129
- Related Material (URI)
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベース雑誌記事索引データベース
- Bibliographic ID (NDL)
- 03283480313120780