Humoral and Cellular Factors Inhibit Phosphate-Induced Vascular Calcification during the Growth Period

• Material Type: 博士論文
• Title: Humoral and Cellular Factors Inhibit Phosphate-Induced Vascular Calcification during the Growth Period
• Author/Editor: Kamei, Yuki; Okumura, Yosuke; Adachi, Yuichiro; Mori, Yuki; Sakai, Maiko; Ohnishi, Kohta; Ohminami, Hirokazu; Masuda, Masashi; Yamanaka-Okumura, Hisami; Taketani, Yutaka
• Author Heading: Kamei, Yuki; Okumura, Yosuke; Adachi, Yuichiro; Mori, Yuki; Sakai, Maiko; Ohnishi, Kohta; Ohminami, Hirokazu; Masuda, Masashi; Yamanaka-Okumura, Hisami; Taketani, Yutaka
• Publication, Distribution, etc.: Society for Free Radical Research Japan
• Publication Date: 2023-11-01
• Publication Date (W3CDTF): 2023-11-01
• Alternative Title: 液性因子および細胞性因子が成長期におけるリン誘導性の血管石灰化を抑制する
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-24
• Date Granted (W3CDTF): 2023-03-24
• Dissertation Number: 甲第3735号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: chronic kidney disease; hyperphosphatemia; fetuin-A; pyrophosphate; alkaline phosphatase
• Target Audience: 一般
• Note (General): Hyperphosphatemia is an independent and non-classical risk factor of cardiovascular disease and mortality in patients with chronic kidney disease (CKD). Increased levels of extracellular inorganic phosphate (Pi) are known to directly induce vascular calcification, but the detailed underlying mechanism has not been clarified. Although serum Pi levels during the growth period are as high as those observed in hyperphosphatemia in adult CKD, vascular calcification does not usually occur during growth. Here, we have examined whether the defence system against Pi-induced vascular calcification can exist during the growth period using mice model. We found that calcification propensity of young serum (aged 3 weeks) was significantly lower than that of ‍adult serum (10 months), possibly due to high fetuin-A levels. In addition, when the aorta was cultured in high Pi medium in ‍vitro, obvious calcification was observed in the adult aorta but ‍not in the young aorta. Furthermore, culture in high Pi medium increased the mRNA level of tissue-nonspecific alkaline phosphatase (TNAP), which degrades pyrophosphate, only in the adult aorta. Collectively, our findings indicate that the aorta in growing mouse may be resistant to Pi-induced vascular calcification via a mechanism in which high serum fetuin-A levels and suppressed TNAP expression.
• Persistent ID (NDL): info:ndljp/pid/13122604; https://dl.ndl.go.jp/pid/13122604
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• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-12-15T22:13:25+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/118316
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