Dietary phosphate disturbs of gut microbiome in mice

Persistent ID (NDL): info:ndljp/pid/13122611

Material type: 博士論文

Author: Oda, Naokoほか

Publisher: Society for Free Radical Research Japan

Publication date: 2023-11-01

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（栄養学）

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Note (General)：: Disorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake of dietary phosphate deterior...

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Material Type: 博士論文
Title: Dietary phosphate disturbs of gut microbiome in mice
Author/Editor: Oda, Naoko
Sugihara, Kohei
Uebanso, Takashi
Ohminami, Hirokazu
Ohnishi, Kohta
Masuda, Masashi
Yamanaka-Okumura, Hisami
Taketani, Yutaka
Author Heading: Oda, Naoko
Sugihara, Kohei
Uebanso, Takashi
Ohminami, Hirokazu
Ohnishi, Kohta
Masuda, Masashi
Yamanaka-Okumura, Hisami
Taketani, Yutaka
Publication, Distribution, etc.: Society for Free Radical Research Japan
Publication Date: 2023-11-01
Publication Date (W3CDTF): 2023-11-01
Alternative Title: 食餌性リンはマウスの腸内環境を変化させる
Degree grantor/type: 徳島大学
Date Granted: 2023-03-24
Date Granted (W3CDTF): 2023-03-24
Dissertation Number: 甲第3732号
Degree Type: 博士（栄養学）
Text Language Code: eng
Subject Heading: hyperphosphatemia
microbiota
chronic kidney disease
tight junction
short chain fatty acids
Target Audience: 一般
Note (General): Disorder of phosphate metabolism is a common pathological condition in chronic kidney disease patients. Excessive intake of dietary phosphate deteriorates chronic kidney disease and various complications including cardiovascular and infectious diseases. Recent reports have demonstrated that gut microbiome disturbance is associated with both the etiology and progression of chronic kidney disease. However, the relationship between dietary phosphate and gut microbiome remains unknown. Here, we examined the effects of excessive intake of phosphate on gut microbiome. Five-week-old male C57BL/6J mice were fed either control diet or high phosphate diet for eight weeks. Analysis of the gut microbiota was carried out using MiSeq next generation sequencer, and short-chain fatty acids were determined with GC-‍MS. In analysis of gut microbiota, significantly increased in Erysipelotrichaceae and decreased in Ruminococcaceae were observed in high phosphate diet group. Furthermore, high phosphate diet induced reduction of microbial diversity and decreased mRNA levels of colonic tight junction markers. These results suggest that the excessive intake of dietary phosphate disturbs gut microbiota and affects intestinal barrier function.
Persistent ID (NDL): info:ndljp/pid/13122611
https://dl.ndl.go.jp/pid/13122611
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-12-15T22:13:25+09:00
Format (IMT): application/pdf
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/118315
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