Effects of the loss of maternal gut microbiota before pregnancy on gut microbiota, food allergy susceptibility, and epigenetic modification on subsequent generations.

• Material Type: 博士論文
• Title: Effects of the loss of maternal gut microbiota before pregnancy on gut microbiota, food allergy susceptibility, and epigenetic modification on subsequent generations.
• Author/Editor: Aizawa, Shinta; Uebanso, Takashi; Shimohata, Takaaki; Mawatari, Kazuaki; Takahashi, Akira
• Author Heading: Aizawa, Shinta; Uebanso, Takashi; Shimohata, Takaaki; Mawatari, Kazuaki; Takahashi, Akira
• Publication, Distribution, etc.: BMFH Press
• Publication Date: 2023
• Publication Date (W3CDTF): 2023
• Alternative Title: 妊娠期前の母親における腸内細菌叢の喪失が以降の世代の腸内細菌叢、食物アレルギー発症、エピゲノム修飾に与える影響について; MATERNAL GUT MICROBIOTA AND FOOD ALLERGY IN OFFSPRING
• Degree grantor/type: 徳島大学
• Date Granted: 2023-03-30
• Date Granted (W3CDTF): 2023-03-30
• Dissertation Number: 甲第3736号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: Developmental Origins of Health and Disease; DNA methylation; gut microbiota; food allergy; antibiotics; Treg (Regulatory T cell)
• Target Audience: 一般
• Note (General): Maternal environments affect the health of offspring in later life. Changes in epigenetic modifications may partially explain this phenomenon. The gut microbiota is a critical environmental factor that influences epigenetic modifications of host immune cells and the development of food allergies. However, whether changes in the maternal gut microbiota affect the development of food allergies and related epigenetic modifications in subsequent generations remains unclear. Here, we investigated the effects of antibiotic treatment before pregnancy on the development of the gut microbiota, food allergies, and epigenetic modifications in F1 and F2 mice. We found that pre-conception antibiotic treatment affected the gut microbiota composition in F1 but not F2 offspring. F1 mice born to antibiotic-treated mothers had a lower proportion of butyric acid-producing bacteria and, consequently, a lower butyric acid concentration in their cecal contents. The methylation level in the DNA of intestinal lamina propria lymphocytes, food allergy susceptibility, and production of antigen-specific IgE in the F1 and F2 mice were not different between those born to control and antibiotic-treated mothers. In addition, F1 mice born to antibiotic-treated mothers showed increased fecal excretion related to the stress response in a novel environment. These results suggest that the maternal gut microbiota is effectively passed onto F1 offspring but has little effect on food allergy susceptibility or DNA methylation levels in offspring.
• Persistent ID (NDL): info:ndljp/pid/13122691; https://dl.ndl.go.jp/pid/13122691
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2023-12-15T22:13:25+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/118320
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp