非ステロイド性抗炎症薬の慢性炎症時における体内動態変動およびアシルグルクロン酸抱合体の加水分解特性と毒性予測に関する研究

Persistent ID (NDL): info:ndljp/pid/13122753

Material type: 博士論文

Author: 生田, 博之

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Publication date: 2023-03-16

Material Format: Digital

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Name of awarding university/degree: 近畿大学,博士（薬科学）

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Note (General)：: 主査：川﨑直人教授　　学内授与番号：薬第192号Hiroyuki Ikuta,Hiroaki Shimada,Kenjiro Sakamoto,Rena Nakamura,Atsushi Kawase, Masahiro Iwaki”Species differences in liver mic...

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Material Type: 博士論文
Title: 非ステロイド性抗炎症薬の慢性炎症時における体内動態変動およびアシルグルクロン酸抱合体の加水分解特性と毒性予測に関する研究
Author/Editor: 生田, 博之
Author Heading: 生田, 博之
Publication Date: 2023-03-16
Publication Date (W3CDTF): 2023-03-16
Alternative Title: The alteration of disposition of non-steroidal anti-inflammatory drugs during chronic inflammation and prediction of drug-induced toxicity by characterization of acyl glucuronide hydrolysis
Degree grantor/type: 近畿大学
Date Granted: 2023-03-16
Date Granted (W3CDTF): 2023-03-16
Dissertation Number: 甲第1555号
Degree Type: 博士（薬科学）
Text Language Code: jpn
Alias of Author: Ikuta, Hiroyuki
Target Audience: 一般
Note (General): 主査：川﨑直人教授　　学内授与番号：薬第192号Hiroyuki Ikuta,Hiroaki Shimada,Kenjiro Sakamoto,Rena Nakamura,Atsushi Kawase, Masahiro Iwaki”Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats” Xenobiotica, Volume 52, 2022, Issue 7, p.653-660https://doi.org/10.1080/00498254.2022.2131484 掲載Hiroaki Shimada, Hiroyuki Ikuta, Keisuke Kumazawa, Manato Nomi, Mayumi Shiojiri, Atsushi Kawase, Masahiro Iwaki "Relationship between the risk of idiosyncratic drug toxicity and formation and degradation profiles of acyl-glucuronide metabolites of nonsteroidal anti-inflammatory drugs in rat liver microsomes" European Journal of Pharmaceutical Sciences, Volume 174, 2022, 106193https://doi.org/10.1016/j.ejps.2022.106193 掲載Hiroyuki Ikuta, Atsushi Kawase and Masahiro Iwaki "Stereoselective Pharmacokinetics and Chiral Inversion of Ibuprofen in Adjuvant-induced Arthritic Rats" Drug Metabolism and Disposition, 2017, 45 (3) 316-324DOI: https://doi.org/10.1124/dmd.116.073239 掲載
DOI: 10.15100/0002000490
https://doi.org/10.15100/0002000490
Persistent ID (NDL): info:ndljp/pid/13122753
https://dl.ndl.go.jp/pid/13122753
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-12-15T22:13:26+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://dx.doi.org/10.15100/0002000490
https://kindai.repo.nii.ac.jp/records/2000490
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp