Desfurane improves lung collapse more than propofol during one-lung ventilation and reduces operation time in lobectomy by video-assisted thoracic surgery : a randomized controlled trial

• Material Type: 博士論文
• Title: Desfurane improves lung collapse more than propofol during one-lung ventilation and reduces operation time in lobectomy by video-assisted thoracic surgery : a randomized controlled trial
• Author/Editor: Kawanishi, Ryosuke; Kakuta, Nami; Sakai, Yoko; Hari, Yuki; Sasaki, Hideto; Sekiguchi, Ryo; Tanaka, Katsuya
• Author Heading: Kawanishi, Ryosuke; Kakuta, Nami; Sakai, Yoko; Hari, Yuki; Sasaki, Hideto; Sekiguchi, Ryo; Tanaka, Katsuya
• Publication, Distribution, etc.: BioMed Central|Springer Nature
• Publication Date: 2022-04-29; 22
• Publication Date (W3CDTF): 2022-04-29
• Alternative Title: プロポフォールと比較してデスフルランは胸腔鏡下肺葉切除術中の肺の虚脱を改善させ手術時間を短縮する
• Degree grantor/type: 徳島大学
• Date Granted: 2024-01-25
• Date Granted (W3CDTF): 2024-01-25
• Dissertation Number: 乙第2130号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Desflurane; Propofol; One-lung ventilation; Lung collapse
• Target Audience: 一般
• Note (General): Background: This study evaluated whether desflurane improved lung collapse during one-lung ventilation (OLV) more than propofol, and whether it could reduce the operation time of video-assisted thoracic surgery.Methods: Sixty patients undergoing lobectomy by video-assisted thoracic surgery (VATS) were randomly assigned to general anesthesia with desflurane or propofol. Lungs were inspected by thoracoscope at 10, 30, and 60 min after initiation of OLV. After surgery, the Lung Collapse Score, a composite of lung color and volume assessments, was assigned by two clinicians blinded to the anesthetic regimen. The primary outcome was operation time. The secondary outcome included the complication rate.Results: Of the 60 participants, 50 completed the study, 26 in Desflurane group and 24 in Propofol group. The Lung Collapse Scores at 30 and 60 min after OLV initiation were significantly better in Desflurane group than in Propofol group, and operation time was significantly shorter in Desflurane group (214 (57) min vs. 262 (72) min [mean (SD)], difference in means, -48; 95% CI, -85 to -11; P = 0.01). The incidence of multiple complications was 1/26 (3%) and 6/24 (25%) in Desflurane and Propofol group, respectively (relative risk, 0.1; 95% CI, 0.02 to 1.18; P = 0.04).Conclusions: Desflurane improved lung collapse during OLV and significantly shortened VATS lobectomy operation time compared to propofol in our studied patients. Desflurane resulted in fewer postoperative complications. Thus, desflurane may be an appropriate anesthetic during lobectomy by VATS requiring OLV.
• Persistent ID (NDL): info:ndljp/pid/13342518; https://dl.ndl.go.jp/pid/13342518
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• Date Accepted (W3CDTF): 2024-03-01T22:05:19+09:00
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/118947
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