Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage

• Material Type: 博士論文
• Title: Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage
• Author/Editor: Kurashiki, Yoshitaka; Kagusa, Hiroshi; Yagi, Kenji; Kinouchi, Tomoya; Sumiyoshi, Manabu; Miyamoto, Takeshi; Shimada, Kenji; Kitazato, Keiko T; Uto, Yoshihiro; Takagi, Yasushi
• Author Heading: Kurashiki, Yoshitaka; Kagusa, Hiroshi; Yagi, Kenji; Kinouchi, Tomoya; Sumiyoshi, Manabu; Miyamoto, Takeshi; Shimada, Kenji; Kitazato, Keiko T; Uto, Yoshihiro; Takagi, Yasushi
• Publication, Distribution, etc.: International Society for Cerebral Blood Flow and Metabolism|Sage
• Publication Date: 2022-12-22; 43 4
• Publication Date (W3CDTF): 2022-12-22
• Alternative Title: 脳梗塞モデルラットにおける虚血後の時期依存的な抗炎症性M2マクロファージ活性化変調の役割
• Degree grantor/type: 徳島大学
• Date Granted: 2023-12-28
• Date Granted (W3CDTF): 2023-12-28
• Dissertation Number: 甲第3766号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Arginase-1; cerebral ischemia; interleukin-4; macrophage modulation; post-ischemic phase
• Target Audience: 一般
• Note (General): Cerebral ischemia triggers inflammatory changes, and early complications and unfavorable outcomes of endovascular thrombectomy for brain occlusion promote the recruitment of various cell types to the ischemic area. Although anti-inflammatory M2-type macrophages are thought to exert protective effects against cerebral ischemia, little has been clarified regarding the significance of post-ischemic phase-dependent modulation of M2-type macrophages. To test our hypothesis that post-ischemic phase-dependent modulation of macrophages represents a potential therapy against ischemic brain damage, the effects on rats of an M2-type macrophage-specific activator, Gc-protein macrophage-activating factor (GcMAF), were compared with vehicle-treated control rats in the acute (day 0–6) or subacute (day 7–13) phase after ischemia induction. Acute-phase GcMAF treatment augmented both anti-inflammatory CD163+M2-type- and pro-inflammatory CD16+ M1-type macrophages, resulting in no beneficial effects. Conversely, subacute-phase GcMAF injection increased only CD163+ M2-type macrophages accompanied by elevated mRNA levels of arginase-1 and interleukin-4. M2-type macrophages co-localized with CD36+ phagocytic cells led to clearance of the infarct area, which were abrogated by clodronate-liposomes. Expression of survival-related molecules on day 28 at the infarct border was augmented by GcMAF. These data provide new and important insights into the significance of M2-type macrophage-specific activation as post-ischemic phase-dependent therapy.
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• Date Accepted (W3CDTF): 2024-04-05T22:42:19+09:00
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/118878
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