Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice

• Material Type: 博士論文
• Title: Spontaneous Occurrence of Various Types of Hepatocellular Adenoma in the Livers of Metabolic Syndrome-Associated Steatohepatitis Model TSOD Mice
• Author/Editor: Shao, Wenhua; Jargalsaikhan, Orgil; Ichimura-Shimizu, Mayuko; Cai, Qinyi; Ogawa, Hirohisa; Miyakami, Yuko; Atsumi, Kengo; Tomita, Mitsuru; Sutoh, Mitsuko; Toyohara, Shunji; Hokao, Ryoji; Kudo, Yasusei; Oya, Takeshi; Tsuneyama, Koichi
• Author Heading: Shao, Wenhua; Jargalsaikhan, Orgil; Ichimura-Shimizu, Mayuko; Cai, Qinyi; Ogawa, Hirohisa; Miyakami, Yuko; Atsumi, Kengo; Tomita, Mitsuru; Sutoh, Mitsuko; Toyohara, Shunji; Hokao, Ryoji; Kudo, Yasusei; Oya, Takeshi; Tsuneyama, Koichi
• Publication, Distribution, etc.: MDPI
• Publication Date: 2022-10-07; 23 19
• Publication Date (W3CDTF): 2022-10-07
• Alternative Title: メタボリックシンドローム関連脂肪性肝炎発症モデルであるTSODマウスの肝臓には種々の亜型の肝細胞腺腫が自然発生する
• Degree grantor/type: 徳島大学
• Date Granted: 2024-02-22
• Date Granted (W3CDTF): 2024-02-22
• Dissertation Number: 乙第2132号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: glutamine synthetase; liver fatty acid-binding protein; serum amyloid A; beta-catenin; malignant transformation; focal nodular hyperplasia; immunostaining; diabetes; hyperlipidemia; HCA-like tumor
• Target Audience: 一般
• Note (General): Male Tsumura-Suzuki Obese Diabetes (TSOD) mice, a spontaneous metabolic syndrome model, develop non-alcoholic steatohepatitis and liver tumors by feeding on a standard mouse diet. Nearly 70% of liver tumors express glutamine synthetase (GS), a marker of hepatocellular carcinoma. In contrast, approximately 30% are GS-negative without prominent nuclear or structural atypia. In this study, we examined the characteristics of the GS-negative tumors of TSOD mice. Twenty male TSOD mice were sacrificed at 40 weeks and a total of 21 tumors were analyzed by HE staining and immunostaining of GS, liver fatty acid-binding protein (L FABP), serum amyloid A (SAA), and beta-catenin. With immunostaining for GS, six (29%) tumors were negative. Based on the histological and immunohistological characteristics, six GS-negative tumors were classified into several subtypes of human hepatocellular adenoma (HCA). One large tumor showed generally similar findings to inflammatory HCA, but contained small atypical foci with GS staining and partial nuclear beta-catenin expression suggesting malignant transformation. GS-negative tumors of TSOD mice contained features similar to various subtypes of HCA. Different HCA subtypes occurring in the same liver have been reported in humans; however, the diversity of patient backgrounds limits the ability to conduct a detailed, multifaceted analysis. TSOD mice may share similar mechanisms of HCA development as in humans. It is timely to review the pathogenesis of HCA from both genetic and environmental perspectives, and it is expected that TSOD mice will make further contributions in this regard.
• Persistent ID (NDL): info:ndljp/pid/13699581; https://dl.ndl.go.jp/pid/13699581
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• Date Accepted (W3CDTF): 2024-06-07T22:11:38+09:00
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/118862
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