VDR is an essential regulator of hair follicle regression through the progression of cell death

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VDR is an essential regulator of hair follicle regression through the progression of cell death

Persistent ID (NDL): info:ndljp/pid/13699606

Material type: 博士論文

Author: Joko, Yudaiほか

Publisher: Life Science Alliance

Publication date: 2023-09-06

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unkno...

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Material Type: 博士論文
Title: VDR is an essential regulator of hair follicle regression through the progression of cell death
Author/Editor: Joko, Yudai
Yamamoto, Yoko
Kato, Shigeaki
Takemoto, Tatsuya
Abe, Masahiro
Matsumoto, Toshio
Fukumoto, Seiji
Sawatsubashi, Shun
Author Heading: Joko, Yudai
Yamamoto, Yoko
Kato, Shigeaki
Takemoto, Tatsuya
Abe, Masahiro
Matsumoto, Toshio
Fukumoto, Seiji
Sawatsubashi, Shun
Publication, Distribution, etc.: Life Science Alliance
Publication Date: 2023-09-06
6 11
Publication Date (W3CDTF): 2023-09-06
Alternative Title: VDRは細胞死の促進による毛包退縮の必須の調節因子である
VDR is a regulator of hair follicle regression
Degree grantor/type: 徳島大学
Date Granted: 2024-03-07
Date Granted (W3CDTF): 2024-03-07
Dissertation Number: 甲第3786号
Degree Type: 博士（医学）
Text Language Code: eng
Subject Heading: Vitamin D recepter
hair follicle
hair cycle
Target Audience: 一般
Note (General): Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in Vdr-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in Vdr-knockout hair follicles, epithelial strands that normally regress during the catagen phase persist as "surviving epithelial strands." Single-cell RNA sequencing analysis suggests that these surviving epithelial strands are formed by cells in the lower part of the hair follicle. These findings emphasize the importance of the regression phase in hair follicle regeneration and establish VDR as a regulator of the catagen stage.
Persistent ID (NDL): info:ndljp/pid/13699606
https://dl.ndl.go.jp/pid/13699606
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2024-06-07T22:11:38+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/119313
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp