Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients

• Material Type: 博士論文
• Title: Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients
• Author/Editor: Yanagihara, Rie; Yamamoto, Yuri; Kawakita, Takako; Noguchi, Hiroki; Yano, Yuya; Hayashi, Noriko; Ohta, Chiaki; Minato, Saki; Kamada, Shuhei; Aoki, Hidenori; Tamura, Kou; Masaki, Rie; Tachibana, Ayaka; Arakaki, Ryosuke; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• Author Heading: Yanagihara, Rie; Yamamoto, Yuri; Kawakita, Takako; Noguchi, Hiroki; Yano, Yuya; Hayashi, Noriko; Ohta, Chiaki; Minato, Saki; Kamada, Shuhei; Aoki, Hidenori; Tamura, Kou; Masaki, Rie; Tachibana, Ayaka; Arakaki, Ryosuke; Yoshida, Kanako; Kato, Takeshi; Irahara, Minoru; Iwasa, Takeshi
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2022-02; 69 1-2
• Publication Date (W3CDTF): 2022-02
• Alternative Title: Biotin levels in blood and follicular fluid; 血中および卵胞液中ビオチン濃度と体外受精/顕微授精患者における妊娠転帰との関連について
• Degree grantor/type: 徳島大学
• Date Granted: 2024-03-22
• Date Granted (W3CDTF): 2024-03-22
• Dissertation Number: 甲第3792号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: biotin; IVF/ICSI; follicular fluid; pregnancy
• Target Audience: 一般
• Note (General): It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.
• Persistent ID (NDL): info:ndljp/pid/13699692; https://dl.ndl.go.jp/pid/13699692
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2024-06-07T22:11:39+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/117015
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp