Randomized, double-blind, crossover, placebo-controlled clinical trial to evaluate the effects of chicken hot water extract on insulin secretion

• Material Type: 博士論文
• Title: Randomized, double-blind, crossover, placebo-controlled clinical trial to evaluate the effects of chicken hot water extract on insulin secretion
• Author/Editor: Fujimoto, Kazuki; Fujii, K.; Kanamori, T.; Murai, K.; Tomura, T.; Tsutsumi, R.; Teramoto, T.; Nonaka, Y.; Sakaue, H.; Matsuo, Y.; Murayama, N.
• Author Heading: Fujimoto, Kazuki; Fujii, K.; Kanamori, T.; Murai, K.; Tomura, T.; Tsutsumi, R.; Teramoto, T.; Nonaka, Y.; Sakaue, H.; Matsuo, Y.; Murayama, N.
• Publication, Distribution, etc.: Verduci Editore
• Publication Date: 2022; 26 7
• Publication Date (W3CDTF): 2022
• Alternative Title: ランダム化、二重盲検、クロスオーバー、プラセボ対照臨床試験による鶏肉熱水抽出物のインスリン分泌能評価; Effect of EOC in enhancing insulin secretion
• Degree grantor/type: 徳島大学
• Date Granted: 2024-03-22
• Date Granted (W3CDTF): 2024-03-22
• Dissertation Number: 甲第3806号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: Essence of chicken; Insulin; Placebo-controlled clinical trial
• Target Audience: 一般
• Note (General): OBJECTIVE: Essence of chicken (EOC), a hot water extract of chicken, is widely consumed in Southeast Asia as a beverage. EOC has an inhibitory effect on the elevation of blood glucose levels and a secretagogue effect on insulin. However, the mechanism by which EOC promotes insulin secretion is unknown. We aimed to verify the postprandial hyperglycemic inhibitory effect and the insulin secretory effect of EOC in healthy adults under appropriate placebo settings. In addition, we aimed to understand the mechanism underlying the insulin secretory effect of EOC.PATIENTS AND METHODS: Thirty-four healthy Japanese adults were fed 68 mL of EOC or control food, followed by 200 g of cooked rice. Blood glucose and plasma insulin levels were measured at 30, 45, 60, 90, and 120 min after the participants ate cooked rice. The trial had a randomized, double-blind, crossover, placebo-controlled design.RESULTS: The ingestion of EOC induced an increase in the maximum blood concentration (Cmax) of insulin and shortened the time required to reach the maximum blood concentration following rice consumption. Ingestion of the test beverage resulted in a significantly higher insulinogenic index than that obtained after ingestion of the control beverage. No side effects were observed in this study. Mechanistic experiments revealed that EOC stimulated significant (p < 0.05) secretion of GLP-1 from NCI-H716 human intestinal L cells at 0.1, 1, and 10 mg/mL.CONCLUSIONS: Consuming EOC when eating rice supports pancreatic function. Daily consumption of EOC could elevate the early-phase insulin response; therefore, it could prevent diabetes in Asians with low insulin secretion.
• Persistent ID (NDL): info:ndljp/pid/13700305; https://dl.ndl.go.jp/pid/13700305
• Collection: 障害者向け資料
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2024-06-07T22:11:42+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/119343
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp