NLRC5の核内輸送および保持によるMHCクラスI転写活性の増強メカニズム

• Material Type: 博士論文
• Title: NLRC5の核内輸送および保持によるMHCクラスI転写活性の増強メカニズム
• Author/Editor: 朱, 宝慧
• Author Heading: 朱, 宝慧
• Publication, Distribution, etc.: Hokkaido University
• Publication Date: 2024-06-28
• Publication Date (W3CDTF): 2024-06-28
• Alternative Title: Mechanisms of NLRC5 nuclear import and retention for enhanced MHC class I transactivation
• Degree grantor/type: 北海道大学
• Date Granted: 2024-06-28
• Date Granted (W3CDTF): 2024-06-28
• Dissertation Number: 甲第16056号
• Degree Type: 博士(医学)
• Text Language Code: eng
• NDC: 490
• Target Audience: 一般
• Note (General): (主査) 教授 福原 崇介, 教授 村上 正晃, 教授 氏家 英之; 医学院（医学専攻）
• DOI: 10.14943/doctoral.k16056; https://doi.org/10.14943/doctoral.k16056
• Persistent ID (NDL): info:ndljp/pid/13731031; https://dl.ndl.go.jp/pid/13731031
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2024-08-02T22:09:18+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://doi.org/10.14943/doctoral.k16056; http://hdl.handle.net/2115/92773
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

Shuai Hou, Dajun Qu, Yue Li, Baohui Zhu, Dapeng Liang, Xinyue Wei, Wei Tang, Qian Zhang, Jiaojiao Hao, Wei Guo, Weijie Wang, Siqi Zhao, Qi Wang, Sikandar Azam, Misbah Khan, Haidong Zhao, Liye Zhang, and Haixin Lei. XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence. Nucleic Acids Research, 2019 Sep 5; 47(15): 8239–8254.

Sikandar Azam, Shuai Hou, Baohui Zhu, Weijie Wang, Tian Hao, Xiangxue Bu, Misbah Khan, and Haixin Lei. Nuclear retention element recruits U1 snRNP components to restrain spliced lncRNAs in the nucleus. RNA Biology, 2019; 16(8): 1001–1009.

Ji-Seung Yoo, Michihito Sasaki, Steven X Cho, Yusuke Kasuga, Baohui Zhu, Ryota Ouda,Yasuko Orba, Paul de Figueiredo, Hirofumi Sawa, Koichi S Kobayashi. SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis. Nature Communication, 2021 Nov 15;12(1):6602.

Yusuke Kasuga, Baohui Zhu, Kyoung-Jin Jang, Ji-Seung Yoo. Innate immune sensing of coronavirus and viral evasion strategies. Experimental & molecular medicine, 2021 May;53(5):723-736.

Baohui Zhu, Ryota Ouda, Paul de Figueiredo, Koichi S. Kobayashi. ORF6, a repressor of the MHC class I pathway: New molecular target for SARS-CoV-2 drug discovery? Expert Opinion on Therapeutic Targets, under review.