Alternative TitleTNF-αで刺激されたヒト口腔上皮細胞の炎症性メディエーターならびに抗酸化タンパク質発現に対するエルシンの影響
Note (General)Periodontitis is a chronic inflammatory disease induced by periodontal disease-causing bacteria. It has been shown that excessive immune response against bacteria is involved in periodontal tissue destruction including alveolar bone resorption. Erucin is a biologically active substance found in cruciferous plants such as arugula, and is classified as an isothiocyanate. No previous studies have attempted to use erucin in the treatment of periodontitis, and there are no papers that have examined the effects of erucin on periodontal resident cells. The purpose of this study was to analyze the effects of erucin on the production of inflammatory and antioxidant mediators produced by tumor necrosis factor (TNF)-α-stimulated TR146 cells, an oral epithelial cell line, including its effects on signaling molecules. Our results indicate that erucin suppresses interleukin (IL)-6 and CXC-chemokine ligand (CXCL)10 production and vascular cell adhesion molecule (VCAM)-1 expression in TNF-α-stimulated TR146 cells. In addition, erucin induced the production of the antioxidant enzymes, Heme Oxygenase (HO)-1 and NAD(P)H quinone dehydrogenase (NQO)1 in TR146 cells. Furthermore, erucin suppressed TNF-α-stimulated nuclear factor (NF)-κB, signal transducer and activator of transcription (STAT)3, and p70S6K-S6 signaling pathways in TR146 cells. We have shown that erucin has anti-inflammatory effects on oral epithelial cells and also induces the production of antioxidant mediators. These results suggest that erucin may provide a new anti-inflammatory agent that can be used in the treatment of periodontitis.
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2024-09-06T22:07:42+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション