Alternative Titleラットの咬筋量低下による実験的歯の移動への影響について
Degree grantor/typeNagasaki University (長崎大学)
Note (General)Background: Previous clinical observational studies have suggested that orthodontic tooth movement (OTM) is related, at least partly, to the mass and/or capabilities of the masticatory muscles.Objectives: Our study aimed to examine the influence of masticatory muscle mass on the OTM in an animal experimental model in which the masseter muscle was modulated by botulinum neurotoxin type A (BTX) injection.Methods: Eighteen Wistar rats were equally divided into two groups: BTX injection and control. BTX was injected bilaterally into the masseter muscles. Three days after the injection, the maxillary left first molars were orthodontically moved for 14 days. At the end of the experiment, micro-computed tomography was performed to evaluate the rate of OTM and bone morphometry. The masseter muscles were weighed and prepared for histological analyses.Results: The masseter muscle mass in the BTX group was less than that in the control group, and histological findings showed atrophy of muscle fibres. The rate of OTM was significantly higher in the BTX group than in the control group. Furthermore, a negative correlation was detected between masseter muscle mass and OTM in the BTX group. Bone morphometry showed no difference between the control and BTX groups.Conclusion: Decreased masseter muscle mass was found to be closely related to an increase in the rate of OTM in rats using BTX injection to modify the masseter muscle mass. Masseter muscle mass could be a predictive factor for OTM in rats injected with BTX.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1496号 学位授与年月日:令和5年3月1日
Author: Keira Arizono-Shimada, Hitoshi Hotokezaka, Yukiko Morita, Airi Ino-Kondo, Yuika Ueda-Ichinose, Yukako Nashiro, Yuka Hotokezaka, Keiko Yoshimi, Stavros Kiliaridis, Noriaki Yoshida
Citation: Journal of Oral Rehabilitation, 49(10), pp. 1012-1019; 2022
identifier:Nagasaki University (長崎大学), 博士(歯学) (2023-03-01)
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2024-11-12T17:29:48+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション