Differentiation of embryonic stem cells into lung-like cells using lung-derived matrix sheets

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Differentiation of embryonic stem cells into lung-like cells using lung-derived matrix sheets

Persistent ID (NDL): info:ndljp/pid/13873310

Material type: 博士論文

Author: Kitamura, Tomotakaほか

Publisher: Elsevier Inc.

Publication date: 2023-12

Material Format: Digital

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Name of awarding university/degree: 奈良県立医科大学,博士（医学）

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Note (General)：: type:ThesisVarious extracellular matrix (ECM) in the lungs regulate tissue development and homeostasis, as well as provide support for cell structures...

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Material Type: 博士論文
Title: Differentiation of embryonic stem cells into lung-like cells using lung-derived matrix sheets
Author/Editor: Kitamura, Tomotaka
Misu, Masayasu
Yoshikawa, Masahide
Ouji, Yukiteru
Author Heading: Kitamura, Tomotaka
Misu, Masayasu
Yoshikawa, Masahide
Ouji, Yukiteru
Publication, Distribution, etc.: Elsevier Inc.
Publication Date: 2023-12
686
Publication Date (W3CDTF): 2023-12
Alternative Title: 肺由来脱細胞化マトリックスシートを用いた ES 細胞から肺細胞への分化誘導
Degree grantor/type: 奈良県立医科大学
Date Granted: 2024-03-14
Date Granted (W3CDTF): 2024-03-14
Dissertation Number: 甲第904号
Degree Type: 博士（医学）
Text Language Code: eng
Subject Heading: extracellular matrix
stem cell
matrix sheets
differentiation
lung
Target Audience: 一般
Note (General): type:Thesis
Various extracellular matrix (ECM) in the lungs regulate tissue development and homeostasis, as well as provide support for cell structures. However, few studies regarding the effects of lung cell differentiation using lung-derived ECM (LM) alone have been reported. The present study investigated the capability of lung-derived matrix sheets (LMSs) to induce lung cell differentiation using mouse embryonic stem (ES) cells. Expressions of lung-related cell markers were significantly upregulated in ES-derived embryoid bodies (EBs) cultured on an LMS for two weeks. Moreover, immunohistochemical analysis of EBs grown on LMSs revealed differentiation of various lung-related cells. These results suggest that an LMS can be used to promote differentiation of stem cells into lung cells.
権利情報：© 2023 Elsevier Inc. All rights reserved.
identifier:Biochemical and Biophysical Research Communications. 2023 Dec, vol.686, article no.149197
identifier:0006-291X
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4355
identifier:Biochemical and Biophysical Research Communications, 686: 149197
Persistent ID (NDL): info:ndljp/pid/13873310
https://dl.ndl.go.jp/pid/13873310
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2024-12-06T22:41:13+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10564/4355
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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