Pattern of adverse drug reactions associated with the use of anticancer drugs in an oncology-based hospital of Nepal

• Material Type: 記事
• Title: Pattern of adverse drug reactions associated with the use of anticancer drugs in an oncology-based hospital of Nepal
• Author/Editor: Ramisa Tamang; Laxman Bharati; Asmita Priyadarshini Khatiwada; Akihiko Ozaki; Sunil Shrestha
• Publication, Distribution, etc.: 日本 : Japan Medical Association
• Publication Date: 2022-10-17
• Publication Date (W3CDTF): 2022-10-17
• Periodical title: JMA Journal
• No. or year of volume/issue: 5(4)
• Volume: 5(4)
• ISSN (Periodical Title): 2433-3298
• ISSN-L (Periodical Title): 2433-328X
• Text Language Code: eng
• DOI: 10.31662/jmaj.2021-0015; https://doi.org/10.31662/jmaj.2021-0015
• Persistent ID (NDL): info:ndljp/pid/14494949; https://dl.ndl.go.jp/pid/14494949
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• Acquisition Basis: インターネット資料収集保存事業（WARP）
• Date Accepted (W3CDTF): 2025-10-21T09:04:40+09:00
• Date Captured (W3CDTF): 2024-09-26
• Format (IMT): application/pdf
• Access Restrictions: インターネット公開
• Availability of remote photoduplication service: 不可
• Periodical Title (URI): https://warp.da.ndl.go.jp/info:ndljp/pid/13747952/www.jmaj.jp/detail.php?id=10.31662%2Fjmaj.2021-0015
• Periodical Title (Persistent ID (NDL)): info:ndljp/pid/14494946; https://dl.ndl.go.jp/pid/14494946
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Summary, etc.: <p><b>Introduction</b>: Adverse drug reactions (ADRs) are among the leading causes of morbidity and mortality worldwide. ADRs of anticancer drugs are ubiquitous. However, in Nepal, studies on chemotherapy-induced ADRs are scarce. Thus, this study aimed to assess the ADRs associated with the use of anticancer drugs and their management along with causality assessment and severity of ADRs.</p><p><b>Methods</b>: A prospective cross-sectional observational and single-center study was conducted at Bhaktapur Cancer Hospital, Nepal, for 6 months. All the patients who fulfilled the study criteria were analyzed to identify ADRs occurring daily. In addition, all collected data were recorded and analyzed using descriptive statistics.</p><p><b>Results:</b> A total of 861 ADRs were detected among 102 cancer patients. The mean ± S.D. age of the patients was 49.93 ± 14.27 years, and each enrolled patient experienced one or more ADRs with a mean ± S.D. of 8.44 ± 3.27. The common ADRs observed were fatigue, anorexia, alopecia, constipation, nausea, vomiting, and neuropathy. Cyclophosphamide, either alone or in combination with other chemotherapeutic agents, was responsible for most ADRs. According to Naranjo's causality assessment algorithm, most of the ADRs belonged to the probable (47.1%) category. Majority (54.9%) of the ADRs were moderate in their severity. Proton pump inhibitors, antiemetic, mouth gargle, protein powders, iron tablets, and multivitamin and mineral tablets were commonly used for ADR management.</p><p><b>Conclusions</b>: The occurrence of chemotherapy-related ADRs in each enrolled patient is a crucial concern. The present study highlights the need for active monitoring of the patients to identify and manage ADRs promptly.</p>
• DOI: 10.31662/jmaj.2021-0015
• Access Restrictions: インターネット公開
• Data Provider (Database): 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• Summary, etc.: <p><b>Introduction</b>: Adverse drug reactions (ADRs) are among the leading causes of morbidity and mortality worldwide. ADRs of anticancer drugs are ubiquitous. However, in Nepal, studies on chemotherapy-induced ADRs are scarce. Thus, this study aimed to assess the ADRs associated with the use of anticancer drugs and their management along with causality assessment and severity of ADRs.</p><p><b>Methods</b>: A prospective cross-sectional observational and single-center study was conducted at Bhaktapur Cancer Hospital, Nepal, for 6 months. All the patients who fulfilled the study criteria were analyzed to identify ADRs occurring daily. In addition, all collected data were recorded and analyzed using descriptive statistics.</p><p><b>Results:</b> A total of 861 ADRs were detected among 102 cancer patients. The mean ± S.D. age of the patients was 49.93 ± 14.27 years, and each enrolled patient experienced one or more ADRs with a mean ± S.D. of 8.44 ± 3.27. The common ADRs observed were fatigue, anorexia, alopecia, constipation, nausea, vomiting, and neuropathy. Cyclophosphamide, either alone or in combination with other chemotherapeutic agents, was responsible for most ADRs. According to Naranjo's causality assessment algorithm, most of the ADRs belonged to the probable (47.1%) category. Majority (54.9%) of the ADRs were moderate in their severity. Proton pump inhibitors, antiemetic, mouth gargle, protein powders, iron tablets, and multivitamin and mineral tablets were commonly used for ADR management.</p><p><b>Conclusions</b>: The occurrence of chemotherapy-related ADRs in each enrolled patient is a crucial concern. The present study highlights the need for active monitoring of the patients to identify and manage ADRs promptly.</p>
• DOI: 10.31662/jmaj.2021-0015; https://doi.org/10.31662/jmaj.2021-0015
• Access Restrictions: インターネット公開
• Related Material (URI): http://id.ndl.go.jp/digimeta/14494949; https://dl.ndl.go.jp/pid/14494949; https://www.jmaj.jp/download.php?id=10.31662/jmaj.2021-0015
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org
• Bibliographic ID (NDL): 14494949; http://id.ndl.go.jp/bib/14494949