歯科修復材料の性能向上に向けた銀複合ジルコニアの調製と抗菌評価

• Material Type: 博士論文
• Title: 歯科修復材料の性能向上に向けた銀複合ジルコニアの調製と抗菌評価
• Author/Editor: 東中尾, 忠洋
• Author Heading: 東中尾, 忠洋
• Publication, Distribution, etc.: IOP Publishing
• Publication Date: 2025-03-25
• Publication Date (W3CDTF): 2025-03-25
• Alternative Title: Preparation and antibacterial evaluation of silver-doped zirconia for enhanced dental restoration performance
• Degree Grantor: 鹿児島大学
• Date Granted: 2025-03-25
• Date Granted (W3CDTF): 2025-03-25
• Dissertation Number: 甲総研第780号
• Degree Type: 博士(歯学)
• Text Language Code: eng
• Subject Heading: ZrO2; Ag; antibacterial activity; sol–gel process
• Target Audience: 一般
• Note (General): 出版タイプ： VoR; 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Because of its superior strength, esthetic properties, and excellent biocompatibility, zirconia is preferred for dental prosthetic such as crowns and bridges. However, zirconia crowns and bridges are susceptible to secondary caries owing to margin leakage. Silver is a well-known antibacterial agent, making it a desirable additive to zirconia crowns and bridges for secondary caries prevention. This study focuses on imparting zirconia composite with antibacterial properties to enhance its protective capacity in dental restorations. We used the sol–gel method to dope Ag into zirconia. Silver-doped zirconia powders were prepared at Zr:Ag molar ratios of 100:0,100:0.1, 100:0.5, 100:1, 100:3, and 100:5 (respective samples denoted as Ag-0, Ag-0.1, Ag-0.5, Ag-1, Ag-3, and Ag-5) and were subjected to firing at various temperatures (400 °C–1000 °C). We performed x-ray diffraction to investigate the crystal phase of these powders and x-ray fluorescence and field emission scanning electron microscopy to analyze their elemental composition and surface morphology, respectively. Moreover, we performed spectrophotometry to determine the L*a*b* color values, conducted dissolution tests, and quantified the Ag content through inductively coupled plasma optical emission spectroscopy. In addition, we studied the antibacterial activity of the samples. Analyses of the samples fired at ⩽600 °C revealed a predominantly white to grayish-white coloration and a tetragonal crystal phase. Firing at ⩾700 °C resulted in gray or dark gray coloration and a monoclinic crystal phase. The Ag content decreased after firing at 900 °C or 1000 °C. Ag-0.5 and above exhibited antibacterial activity against both Escherichia coli and Staphylococcus aureus. Therefore, the minimum effective silver-doped zirconia sample was found to be Ag-0.5. This study allows the exploration of the antimicrobial potential of silver-doped zirconia materials in dental applications such as prosthdontical lining materials, promoting the development of innovative restorations with protective capacity against secondary caries.; Tadahiro Higashinakao, Hiroshi Kono, Mihiro Itotagawa, Yuki Sugiura, Yuta Otsuka and Masafumi KikuchiPreparation and antibacterial evaluation of silver-doped zirconia for enhanced dental restoration performanceBiomed. Mater. 19 (2024) 055033https://doi.org/10.1088/1748-605X/ad6ac3
• Persistent ID (NDL): info:ndljp/pid/14551110; https://dl.ndl.go.jp/pid/14551110
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2025-11-07T22:06:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/0002000860
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp