Delayed maturation and differentiation of neurons in focal cortical dysplasia with the transmantle sign: analysis of layer-specific marker expression

• Material Type: 博士論文
• ISSN: 0022-3069
• Title: Delayed maturation and differentiation of neurons in focal cortical dysplasia with the transmantle sign: analysis of layer-specific marker expression
• Volume: 71 8
• Author/Editor: Sakakibara, Takafumi; Sukigara, Sayuri; Saito, Takashi; Otsuki, Taisuke; Takahashi, Akio; Kaneko, Yuu; Kaido, Takanobu; Saito, Yuko; Sato, Noriko; Kimura, Yukio; Nakagawa, Eiji; Sugai, Kenji; Sasaki, Masayuki; Goto, Yu-ichi; Itoh, Masayuki
• Author Heading: Sakakibara, Takafumi; Sukigara, Sayuri; Saito, Takashi; Otsuki, Taisuke; Takahashi, Akio; Kaneko, Yuu; Kaido, Takanobu; Saito, Yuko; Sato, Noriko; Kimura, Yukio; Nakagawa, Eiji; Sugai, Kenji; Sasaki, Masayuki; Goto, Yu-ichi; Itoh, Masayuki
• Publication, Distribution, etc.: Waverly Press
• Publication Date: 2012-08; 71 8
• Publication Date (W3CDTF): 2012-08
• Alternative Title: “Transmantle sign”を示す限局性皮質異形成における神経細胞の成熟と分化の未熟性：層特異的マーカー発現による解析
• Periodical title: Journal of neuropathology and experimental neurology
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2013-05-29
• Date Granted (W3CDTF): 2013-05-29
• Dissertation Number: 乙第1312号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1312号
• Text Language Code: und
• Subject Heading: Epilepsy; Focal cortical dysplasia; Layer-specific markers; Neural maturation; Transmantle dysplasia; Transmantle sign
• Target Audience: 一般
• Note (General): type:Thesis; Transmantle dysplasia is a rare type of focal cortical dysplasia (FCD) characterized by expansion of the cortex from the deep white matter to the surface and in which there is a FCD IIA or IIB pathologic pattern. To characterize possible mechanisms underlying this regional disorder of radial migrating cells, we studied the expression patterns of neocortical layer-specific markers using immunohistochemistry in surgical specimens from 5 FCD IIA and 4 FCD IIB cases in children. All neuronal cells expressed the mature neuron marker MAP2/2B but not the microglia markers Iba-1 and CD68. Some layer-specific markers showed distinct expression patterns. TBR1-positive, SATB2-positive, and FOXP1-positive cells were diffusely distributed in the cortex and/or the white matter. TBR1-positive and FOXP1-positive cells were generally more numerous in FCD IIB than in FCD IIA and were mostly in the cortical molecular and upper layers. FOXP1-, FOXP2-, and CUTL1-positive cells also expressed the immature neuron marker, Nestin/PROX1, whereas TBR1-, CTIP2-, and SATB2-positive cells only expressed MAP2/2B. These data highlight differences between FCD IIB and FCD IIA with more cells having the immature marker in upper layer markers in the former. By analyzing layer-specific marker expression patterns, we identified apparent neuronal maturation differences between FCD IIA and FCD IIB in cases of transmantle dysplasia.; 博士（医学）・乙第1312号・平成25年5月29日; identifier:Journal of neuropathology and experimental neurology Vol.71 No.8 p.741-749; identifier:00223069; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2590; identifier:Journal of neuropathology and experimental neurology, 71(8): 741-749
• DOI: info:doi/10.1097/NEN.0b013e318262e41a; https://doi.org/info:doi/10.1097/NEN.0b013e318262e41a
• Persistent ID (NDL): info:ndljp/pid/8948167; https://dl.ndl.go.jp/pid/8948167
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Available (W3CDTF): 2015-03-03
• Date Accepted (W3CDTF): 2015-02-03T05:25:05+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/2590
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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